Shen Zhe, Munker Stefan, Wang Chenyang, Xu Lei, Ye Hua, Chen Hongtan, Xu Genyun, Zhang Hong, Chen Lihua, Yu Chaohui, Li Youming
Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003 Hangzhou, China.
Molecular Hepatology-Alcohol Associated Diseases, II. Medical Clinic Faculty of Medicine at Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
J Clin Lipidol. 2014 May-Jun;8(3):273-8. doi: 10.1016/j.jacl.2014.02.003. Epub 2014 Feb 14.
Alcohol, overweight, and lipid metabolism contribute to fatty liver and atherosclerosis pathogenesis.
To study the association of alcoholic intake, overweight, and dyslipidemia.
We randomly selected 482 age- and sex-matched individuals from East China. Gender, age, education level, smoking, hypertension, daily alcohol intake, drinking duration, and body mass index (BMI) were evaluated in association with triglyceride, total cholesterol, high-density (HDL-C), and low-density lipoprotein-cholesterol.
The association between dyslipidemia and 8 predictors of disease was made by regression analysis through the generalized additive model. The results showed that age, daily alcohol intake, and BMI were all closely associated with hypertriglyceridemia. Age, duration of drinking, and BMI were all closely associated with hypercholesterolemia. Age and BMI status were both closely associated with high LDL-C levels. By contrast, none of the 8 predictors was closely associated with low HDL-C levels (all P < .05).
Daily alcohol intake was a risk factor for hypertriglyceridemia. By contrast, drinking duration was a protective factor against hypercholesterolemia. Age and BMI were important risk factors for dyslipidemia (excluding HDL-C).
酒精、超重及脂质代谢与脂肪肝和动脉粥样硬化的发病机制有关。
研究酒精摄入量、超重与血脂异常之间的关联。
我们从中国东部地区随机选取了482名年龄和性别匹配的个体。对性别、年龄、教育水平、吸烟情况、高血压、每日酒精摄入量、饮酒时长及体重指数（BMI）与甘油三酯、总胆固醇、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇进行了相关性评估。
通过广义相加模型进行回归分析得出了血脂异常与8种疾病预测因素之间的关联。结果显示，年龄、每日酒精摄入量和BMI均与高甘油三酯血症密切相关。年龄、饮酒时长和BMI均与高胆固醇血症密切相关。年龄和BMI状态均与高LDL-C水平密切相关。相比之下，这8种预测因素均与低HDL-C水平无密切关联（所有P<0.05）。
每日酒精摄入量是高甘油三酯血症的一个危险因素。相比之下，饮酒时长是预防高胆固醇血症的一个保护因素。年龄和BMI是血脂异常（不包括HDL-C）的重要危险因素。
