镍催化2-氯吡啶与溴代烷烃的交叉亲电偶联反应。
Nickel-catalyzed cross-electrophile coupling of 2-chloropyridines with alkyl bromides.
作者信息
Everson Daniel A, Buonomo Joseph A, Weix Daniel J
机构信息
Department of Chemistry, University of Rochester, Rochester, NY 14627-0216 USA.
出版信息
Synlett. 2014 Jan;25(2):233-238. doi: 10.1055/s-0033-1340151.
Abstract
The synthesis of 2-alkylated pyridines by the nickel-catalyzed cross-coupling of two different electrophiles, 2-chloropyridines with alkyl bromides, is described. Compared to our previously published conditions for aryl halides, this method uses the different, more rigid bathophenanthroline ligand and is conducted at high concentration in DMF solvent. The method displays promising functional group compatibility and the conditions are orthogonal to the Stille coupling.
摘要
本文描述了通过镍催化两种不同亲电试剂（2-氯吡啶与烷基溴）的交叉偶联反应合成2-烷基吡啶的方法。与我们之前报道的用于芳基卤化物的条件相比，该方法使用了不同的、刚性更强的红菲绕啉配体，并且在DMF溶剂中高浓度下进行。该方法显示出良好的官能团兼容性，且这些条件与Stille偶联反应相互正交。
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