The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences , Guiyang 550002, PR China.
Org Lett. 2014 May 16;16(10):2696-9. doi: 10.1021/ol5009763. Epub 2014 May 5.
Vulgarisin A (1), a new diterpenoid with an unprecedented 5/6/4/5 fused tetracyclic ring skeleton, has been isolated from the medicinal plant Prunella vulgaris Linn. Its structure was characterized by extensive spectroscopic methods, and the absolute configuration was secured by single crystal X-ray diffraction analysis. Compound 1 showed weak cytotoxicity against human lung carcinoma A549 cells with an IC50 value of 57.0 μM.
猪毛菜素 A（1），一种新型二萜类化合物，具有前所未有的 5/6/4/5 稠合四环骨架，从药用植物夏枯草中分离得到。其结构通过广泛的光谱方法进行了表征，并通过单晶 X 射线衍射分析确定了绝对构型。化合物 1 对人肺癌 A549 细胞表现出较弱的细胞毒性，IC50 值为 57.0 μM。
