化脓性汗腺炎的风险因素、临床病程和长期预后：一项横断面研究。
Risk factors, clinical course and long-term prognosis in hidradenitis suppurativa: a cross-sectional study.
机构信息
Department of Dermatology, Health Sciences Faculty, Roskilde Hospital, University of Copenhagen, Copenhagen, Denmark.
出版信息
Br J Dermatol. 2014 Oct;171(4):819-24. doi: 10.1111/bjd.13090. Epub 2014 Sep 7.
BACKGROUND
Hidradenitis suppurativa (HS) causes considerable morbidity. The long-term prognosis is of obvious interest to both patients and physicians. We conducted this study to determine the prognosis and risk factors in patients diagnosed with HS.
OBJECTIVES
To describe the long-term prognosis and the clinical course of HS and its association to known risk factors.
METHODS
A postal follow-up survey with uncomplicated factual questions was conducted. As all of the patients were well acquainted with their long-standing disease, this was thought to be sufficient for meaningful results. All cases were diagnosed by a dermatologist. Overall, 212 patients diagnosed with HS between 1981 and 2001 were studied after a median follow-up period of 22 years (range 12-32).
RESULTS
The overall response rate was 71.2%, with 60.8% (129/212) valid (fully completed) questionnaires. Remission was reported by 39.4% (50/127) and improvement by 31.5% (40/127). Unchanged severity was reported by 20.5% (26/127), and 8.7% (11/127) experienced worsening disease. Tobacco smoking was reported by 92.2% (119/129). Among nonsmokers, 40% (35/88) reported remission vs. 29% (17/59) of active smokers. A higher proportion of nonobese patients (45%) reported remission than obese patients (23%).
CONCLUSIONS
We found that 39.4% of the sample reported remission of HS. Suspected risk factors appeared to influence the prognosis. Smoking and obesity were significantly linked to a lower rate of self-reported remission. The notion that lifestyle factors play a role in HS appears to be supported by this survey.
背景
化脓性汗腺炎（HS）可导致相当大的发病率。长期预后对患者和医生都具有明显的意义。我们进行这项研究旨在确定患有 HS 的患者的预后和危险因素。
目的
描述 HS 的长期预后和临床过程及其与已知危险因素的关联。
方法
进行了一项邮寄随访调查，其中包含简单的事实问题。由于所有患者都非常了解自己的长期疾病，因此认为这足以获得有意义的结果。所有病例均由皮肤科医生诊断。总体而言，在中位随访 22 年（范围 12-32 年）后，研究了 1981 年至 2001 年间诊断为 HS 的 212 例患者。
结果
总应答率为 71.2％，212 例患者中有 60.8％（129/212）有效（完整填写）的调查问卷。39.4％（50/127）报告缓解，31.5％（40/127）报告改善。20.5％（26/127）报告病情无变化，8.7％（11/127）报告病情恶化。92.2％（119/127）报告吸烟。在不吸烟者中，40％（35/88）报告缓解，而吸烟者中为 29％（17/59）。非肥胖患者（45％）报告缓解的比例高于肥胖患者（23％）。
结论
我们发现，样本中有 39.4％的患者报告 HS 缓解。疑似危险因素似乎影响预后。吸烟和肥胖与自我报告缓解的比例降低显著相关。这项调查似乎支持生活方式因素在 HS 中起作用的观点。
Zotero 插件