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本文引用的文献

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Biomarkers of exposure to polycyclic aromatic hydrocarbons (PAHs) and DNA damage: a cross-sectional pilot study among roofers in South Florida.多环芳烃（PAHs）暴露与DNA损伤的生物标志物：南佛罗里达州屋顶工人群体的一项横断面试点研究。
BMJ Open. 2012 Jul 19;2(4). doi: 10.1136/bmjopen-2012-001318. Print 2012.
2
Characterization of inhalation exposure to jet fuel among U.S. Air Force personnel.美国空军人员吸入喷气燃料暴露情况的特征分析
Ann Occup Hyg. 2012 Jul;56(6):736-45. doi: 10.1093/annhyg/mes014. Epub 2012 Mar 20.
3
Urinary biomarkers of occupational jet fuel exposure among Air Force personnel.空军人员职业喷气燃料暴露的尿生物标志物。
J Expo Sci Environ Epidemiol. 2012 Jan-Feb;22(1):35-45. doi: 10.1038/jes.2011.38. Epub 2011 Nov 2.
4
The Occupational JP8 Exposure Neuroepidemiology Study (OJENES): repeated workday exposure and central nervous system functioning among US Air Force personnel.职业 JP8 暴露神经流行病学研究（OJENES）：美国空军人员工作日重复暴露与中枢神经系统功能。
Neurotoxicology. 2011 Dec;32(6):799-808. doi: 10.1016/j.neuro.2011.06.010. Epub 2011 Jul 28.
5
Inhalation exposure to jet fuel (JP8) among U.S. Air Force personnel.美国空军人员喷气燃料（JP8）吸入暴露。
J Occup Environ Hyg. 2010 Oct;7(10):563-72. doi: 10.1080/15459624.2010.503755.
6
Variability of urinary concentrations of polycyclic aromatic hydrocarbon metabolite in general population and comparison of spot, first-morning, and 24-h void sampling.人群尿液中多环芳烃代谢产物浓度的变异性及点尿、晨尿和 24 小时排空尿采样的比较。
J Expo Sci Environ Epidemiol. 2010 Sep;20(6):526-35. doi: 10.1038/jes.2009.41. Epub 2009 Aug 26.
7
Measurement of urinary monohydroxy polycyclic aromatic hydrocarbons using automated liquid-liquid extraction and gas chromatography/isotope dilution high-resolution mass spectrometry.采用自动液液萃取和气相色谱/同位素稀释高分辨率质谱法测定尿中单羟基多环芳烃
Anal Chem. 2006 Aug 15;78(16):5744-51. doi: 10.1021/ac0606094.
8
Glutathione-S-transferase M1, obesity, statins, and autonomic effects of particles: gene-by-drug-by-environment interaction.谷胱甘肽-S-转移酶M1、肥胖、他汀类药物与颗粒物的自主神经效应：基因-药物-环境相互作用
Am J Respir Crit Care Med. 2005 Dec 15;172(12):1529-33. doi: 10.1164/rccm.200412-1698OC. Epub 2005 Jul 14.
9
Dose-dependent production of urinary naphthols among workers exposed to jet fuel (JP-8).接触喷气燃料（JP-8）的工人尿萘酚的剂量依赖性产生。
Am J Ind Med. 2004 Sep;46(3):234-44. doi: 10.1002/ajim.20049.
10
Benzene and naphthalene in air and breath as indicators of exposure to jet fuel.空气中和呼出气体中的苯和萘作为接触喷气燃料的指标。
Occup Environ Med. 2003 Dec;60(12):969-76. doi: 10.1136/oem.60.12.969.

美国空军人员接触喷气燃料后尿中环多芳烃（OH-PAH）代谢物浓度与 GST 多态性的关系。

Urinary polycyclic aromatic hydrocarbon (OH-PAH) metabolite concentrations and the effect of GST polymorphisms among US Air Force personnel exposed to jet fuel.

机构信息

From the Department of Environmental Health (Drs Rodrigues and Smith), Harvard School of Public Health, Boston; Department of Environmental Health (Ms Maule and Drs Proctor and McClean), Boston University School of Public Health, Mass; Organic Analytical Toxicology Branch (Drs Sjodin and Li and Ms Romanoff), Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Ga; Department of Epidemiology (Dr Kelsey), Brown University School of Medicine, Providence, RI; Military Performance Division (Dr Proctor), US Army Research Institute of Environmental Medicine, Natick; and VA Boston Healthcare System (Dr Proctor), Mass.

出版信息

J Occup Environ Med. 2014 May;56(5):465-71. doi: 10.1097/JOM.0000000000000142.

DOI:10.1097/JOM.0000000000000142
PMID:24806557
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5137189/
Abstract

OBJECTIVE

To evaluate the association between inhalation exposure to jet propulsion fuel 8 (JP-8) and urinary metabolites among US Air Force (USAF) personnel, and investigate the role of glutathione S-transferase polymorphisms.

METHODS

Personal air samples were collected from 37 full-time USAF personnel during 4 consecutive workdays and analyzed for JP-8 constituents and total hydrocarbons. Pre- and postshift urine samples were collected each day and analyzed for polycyclic aromatic hydrocarbon urinary metabolites.

RESULTS

Work shift exposure to total hydrocarbons was significantly associated with postshift urinary 1-naphthol (β = 0.17; P = <0.0001), 2-naphthol (β = 0.09; P = 0.005), and 2-hydroxyfluorene concentrations (β = 0.08; P = 0.006), and a significant gene-environment interaction was observed with glutathione S-transferase mu-1.

CONCLUSIONS

USAF personnel experience inhalation exposure to JP-8, which is associated with absorption of JP-8 constituents while performing typical job-related tasks, and in our data the glutathione S-transferase mu-1 polymorphism was associated with differential metabolism of naphthalene.

摘要

目的

评估喷气推进燃料 8（JP-8）吸入暴露与美国空军（USAF）人员尿液代谢物之间的关系，并研究谷胱甘肽 S-转移酶多态性的作用。

方法

在连续 4 个工作日内，从 37 名全职 USAF 人员中采集个人空气样本，并对 JP-8 成分和总碳氢化合物进行分析。每天采集班前和班后尿液样本，并分析多环芳烃尿液代谢物。

结果

工作班次总碳氢化合物暴露与班后尿 1-萘酚（β=0.17；P<0.0001）、2-萘酚（β=0.09；P=0.005）和 2-羟基芴浓度（β=0.08；P=0.006）显著相关，并且观察到谷胱甘肽 S-转移酶 mu-1 存在显著的基因-环境相互作用。

结论

USAF 人员经历 JP-8 的吸入暴露，这与在执行典型的与工作相关的任务时吸收 JP-8 成分有关，在我们的数据中，谷胱甘肽 S-转移酶 mu-1 多态性与萘的不同代谢有关。