Maule Alexis L, Proctor Susan P, Blount Benjamin C, Chambers David M, McClean Michael D
Department of Environmental Health (Ms Maule, Dr Proctor, Dr McClean), Boston University School of Public Health; Division of Military Performance (Ms Maule, Dr Proctor), United States Army Research Institute of Environmental Medicine, Natick; Veterans Affairs Boston Healthcare System (Dr Proctor), Massachusetts; National Center for Environmental Health (Dr Blount, Dr Chambers), Centers for Disease Control and Prevention, Atlanta, Georgia.
J Occup Environ Med. 2016 Jan;58(1):24-9. doi: 10.1097/JOM.0000000000000611.
This study aimed to evaluate blood volatile organic compound (VOC) levels as biomarkers of occupational jet propulsion fuel 8 (JP-8) exposure while controlling for smoking.
Among 69 Air Force personnel, post-shift blood samples were analyzed for components of JP-8, including ethylbenzene, toluene, o-xylene, and m/p-xylene, and for the smoking biomarker, 2,5-dimethylfuran. JP-8 exposure was characterized based on self-report and measured work shift levels of total hydrocarbons in personal air. Multivariate regression was used to evaluate the relationship between JP-8 exposure and post-shift blood VOCs while controlling for potential confounding from smoking.
Blood VOC concentrations were higher among US Air Force personnel who reported JP-8 exposure and work shift smoking. Breathing zone total hydrocarbons was a significant predictor of VOC blood levels, after controlling for smoking.
These findings support the use of blood VOCs as a biomarker of occupational JP-8 exposure.
本研究旨在评估血液挥发性有机化合物（VOC）水平，将其作为职业性接触喷气燃料8（JP - 8）的生物标志物，同时控制吸烟因素的影响。
在69名空军人员中，对他们下班后的血液样本进行分析，检测其中JP - 8的成分，包括乙苯、甲苯、邻二甲苯和间/对二甲苯，以及吸烟生物标志物2,5 - 二甲基呋喃。根据自我报告和个人空气中总烃的实测工作班次水平来表征JP - 8暴露情况。采用多变量回归分析来评估JP - 8暴露与下班后血液VOC之间的关系，同时控制吸烟可能造成的混杂影响。
报告有JP - 8暴露和工作班次吸烟情况的美国空军人员血液VOC浓度更高。在控制吸烟因素后，呼吸区总烃是血液VOC水平的一个重要预测指标。
这些研究结果支持将血液VOC用作职业性JP - 8暴露的生物标志物。
