Klijanienko J, Micheau C, Carlu C, Caillaud J M
Department of Histopathology A, Institut Gustave-Roussy, Villejuif, France.
Virchows Arch A Pathol Anat Histopathol. 1989;416(2):121-4. doi: 10.1007/BF01606316.
It has been suggested that cytokeratin 13 is a useful marker of malignancy. We examined normal squamous cell epithelia, hyperplasia, dysplasias of various grades, intraepithelial neoplasia and invasive squamous cell carcinomas of the pyriform fossa using K13 and KL1. Positive staining for K13 was seen in all normal or hyperplastic benign epithelia, was inconstant in dysplasia, and intraepithelial neoplasia and carcinoma was negative. KL1 expression is constant and non significant. These results suggest that tumour cells are unable to synthesize keratin 13 a finding which may be valuable in surgical pathology.
有人提出细胞角蛋白13是一种有用的恶性肿瘤标志物。我们使用K13和KL1检测了梨状窝的正常鳞状上皮、增生、不同级别的发育异常、上皮内瘤变和浸润性鳞状细胞癌。在所有正常或增生性良性上皮中均可见K13阳性染色，在发育异常、上皮内瘤变中不恒定，而在癌中为阴性。KL1表达恒定且无显著差异。这些结果表明肿瘤细胞无法合成角蛋白13，这一发现可能在外科病理学中具有重要价值。
