Napier Johnathan A, Haslam Richard P, Beaudoin Frederic, Cahoon Edgar B
Department of Biological Chemistry, Rothamsted Research, Harpenden, Herts, AL5 2JQ, UK.
Department of Biological Chemistry, Rothamsted Research, Harpenden, Herts, AL5 2JQ, UK.
Curr Opin Plant Biol. 2014 Jun;19(100):68-75. doi: 10.1016/j.pbi.2014.04.001. Epub 2014 May 6.
The manipulation of plant seed oil composition so as to deliver enhanced fatty acid compositions suitable for feed or fuel has long been a goal of metabolic engineers. Recent advances in our understanding of the flux of acyl-changes through different key metabolic pools such as phosphatidylcholine and diacylglycerol have allowed for more targeted interventions. When combined in iterative fashion with further lipidomic analyses, significant breakthroughs in our capacity to generate plants with novel oils have been achieved. Collectively these studies, working at the interface between metabolic engineering and synthetic biology, demonstrate the positive fundamental and applied outcomes derived from such research.
操纵植物种子油的成分以提供适合饲料或燃料的增强型脂肪酸组成，长期以来一直是代谢工程师的目标。我们对酰基通过不同关键代谢库（如磷脂酰胆碱和二酰甘油）的通量的理解取得了最新进展，这使得更有针对性的干预成为可能。当与进一步的脂质组学分析以迭代方式结合时，我们在培育具有新型油脂的植物方面取得了重大突破。这些研究共同处于代谢工程和合成生物学的交叉领域，展示了此类研究带来的积极的基础和应用成果。
