Liu Chunrong, Chen Wei, Shi Wen, Peng Bo, Zhao Yu, Ma Huimin, Xian Ming
Department of Chemistry, Washington State University , Pullman, Washington 99164, United States.
J Am Chem Soc. 2014 May 21;136(20):7257-60. doi: 10.1021/ja502968x. Epub 2014 May 12.
Reactive sulfur species have received considerable attention due to their various biological functions. Among these molecules, hydrogen polysulfides (H2S(n), n > 1) are recently suggested to be the actual signaling molecules derived from hydrogen sulfide (H2S). Hydrogen polysulfides may also have their own biosynthetic pathways. The research on H2S(n) is rapidly growing. However, the detection of H2S(n) is still challenging. In this work we report a H2S(n)-mediated benzodithiolone formation under mild conditions. Based on this reaction, specific fluorescent probes for H2S(n) are prepared and evaluated. The probe DSP-3 shows good selectivity and sensitivity for H2S(n).
由于其多种生物学功能，活性硫物种受到了广泛关注。在这些分子中，多硫化氢（H2S(n)，n>1）最近被认为是源自硫化氢（H2S）的实际信号分子。多硫化氢也可能有其自身的生物合成途径。关于H2S(n)的研究正在迅速发展。然而，H2S(n)的检测仍然具有挑战性。在这项工作中，我们报道了在温和条件下H2S(n)介导的苯并二硫酮形成。基于此反应，制备并评估了用于H2S(n)的特异性荧光探针。探针DSP-3对H2S(n)表现出良好的选择性和灵敏度。
