Albus A, Saalmann M, Tesch H, Pedersen S S, Döring G
Hygiene-Institut, University of Tübingen, Federal Republic of Germany.
APMIS. 1989 Dec;97(12):1146-8. doi: 10.1111/j.1699-0463.1989.tb00531.x.
IgG subclass levels to Pseudomonas aeruginosa alginate, alkaline proteinase, elastase and exotoxin A in sera of healthy adults, non-infected and infected cystic fibrosis patients were investigated by enzyme linked immunosorbent assay. Whereas healthy adults and non-infected cystic fibrosis patients revealed mostly negative IgG subclass levels to the four antigens, infected cystic fibrosis patients had significantly elevated IgG1, IgG2, IgG3 and IgG4 levels to both the protein antigens as well as the polysaccharide antigen. The study does not support previous findings of an impaired natural IgG2 response to polysaccharide antigen. The study does not support previous findings of an impaired natural IgG2 response to polysaccharide in chronically infected cystic fibrosis patients.
采用酶联免疫吸附测定法，对健康成年人、未感染及已感染囊性纤维化患者血清中针对铜绿假单胞菌藻酸盐、碱性蛋白酶、弹性蛋白酶和外毒素A的IgG亚类水平进行了研究。健康成年人和未感染囊性纤维化患者对这四种抗原的IgG亚类水平大多呈阴性，而感染的囊性纤维化患者针对蛋白质抗原和多糖抗原的IgG1、IgG2、IgG3和IgG4水平均显著升高。该研究不支持先前关于对多糖抗原的天然IgG2反应受损的研究结果。该研究不支持先前关于慢性感染的囊性纤维化患者对多糖的天然IgG2反应受损的研究结果。
