Natural Products Research Institute, College of Pharmacy, Seoul National University , San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
Org Lett. 2014 Jun 6;16(11):2826-9. doi: 10.1021/ol500868s. Epub 2014 May 13.
Gombaspiroketals A-C (1-3), tetracyclic sesterterpenes of a novel skeletal class, were isolated from the Korean marine sponge Clathria gombawuiensis. On the basis of the combined spectroscopic analyses, the structures of these compounds were determined to be highly rearranged sesterterpene spiroketal methoxyacetals (1 and 2) and a corresponding hemiacetal (3). The relative and absolute configurations were assigned by NOESY analysis and ECD calculations, respectively. These compounds exhibited moderate cytotoxicities and antibacterial activities.
Gombaspiroketals A-C（1-3）是从韩国海洋海绵 Clathria gombawuiensis 中分离得到的新型四环倍半萜骨架的化合物。基于综合光谱分析，这些化合物的结构被确定为高度重排的倍半萜螺环缩醛甲氧基缩醛（1 和 2）和相应的半缩醛（3）。通过 NOESY 分析和 ECD 计算分别确定了它们的相对和绝对构型。这些化合物表现出中等的细胞毒性和抗菌活性。
