配体促进的三重C-H活化反应：由丙酰胺一锅法合成多种4-芳基-2-喹啉酮。
Ligand-enabled triple C-H activation reactions: one-pot synthesis of diverse 4-aryl-2-quinolinones from propionamides.
作者信息
Deng Youqian, Gong Wei, He Jian, Yu Jin-Quan
机构信息
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA).
出版信息
Angew Chem Int Ed Engl. 2014 Jun 23;53(26):6692-5. doi: 10.1002/anie.201403878. Epub 2014 May 14.
Abstract
Diverse 4-aryl-2-quinolinones are prepared from propionamides in one pot by ligand-promoted triple sequential C-H activation reactions and a stereospecific Heck reaction. In these cascade reactions, three new C-C bonds and one C-N bond are formed to rapidly build molecular complexity from propionic acid.
摘要
通过配体促进的三步连续C-H活化反应和立体选择性Heck反应，在一锅法中由丙酰胺制备了多种4-芳基-2-喹啉酮。在这些串联反应中，形成了三个新的C-C键和一个C-N键，从而从丙酸快速构建分子复杂性。
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