肺部超极化惰性气体磁共振成像：临床应用的最新进展与展望
Pulmonary hyperpolarized noble gas MRI: recent advances and perspectives in clinical application.
作者信息
Liu Zaiyi, Araki Tetsuro, Okajima Yuka, Albert Mitchell, Hatabu Hiroto
机构信息
Center for Pulmonary Functional Imaging, Department of Radiology; Brigham and Women's Hospital, Harvard Medical School, Boston, USA; Department of Radiology, Guangdong General Hospital Guangdong Academy of Medical Sciences, China.
Center for Pulmonary Functional Imaging, Department of Radiology; Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
出版信息
Eur J Radiol. 2014 Jul;83(7):1282-1291. doi: 10.1016/j.ejrad.2014.04.014. Epub 2014 Apr 30.
The invention of hyperpolarized (HP) noble gas MRI using helium-3 ((3)He) or xenon-129 ((129)Xe) has provided a new method to evaluate lung function. Using HP (3)He or (129)Xe for inhalation into the lung air spaces as an MRI contrast agent significantly increases MR signal and makes pulmonary ventilation imaging feasible. This review focuses on important aspects of pulmonary HP noble gas MRI, including the following: (1) functional imaging types, (2) applications for major pulmonary diseases, (3) safety considerations, and (4) future directions. Although it is still challenging to use pulmonary HP noble gas MRI clinically, the technology offers promise for the investigation of the microstructure and function of the lungs.
使用氦 - 3（³He）或氙 - 129（¹²⁹Xe）的超极化（HP）惰性气体磁共振成像（MRI）的发明为评估肺功能提供了一种新方法。将HP ³He或¹²⁹Xe吸入肺腔作为MRI造影剂可显著增加磁共振信号，使肺通气成像成为可能。本综述重点关注肺部HP惰性气体MRI的重要方面，包括以下内容：（1）功能成像类型，（2）在主要肺部疾病中的应用，（3）安全考虑因素，以及（4）未来方向。尽管在临床上使用肺部HP惰性气体MRI仍具有挑战性，但该技术为研究肺的微观结构和功能带来了希望。
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