Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Babraham Research Campus, Cambridge, UK.
Nat Immunol. 2014 Jun;15(6):484-91. doi: 10.1038/ni.2887.
The rapid changes in gene expression that accompany developmental transitions, stress responses and proliferation are controlled by signal-mediated coordination of transcriptional and post-transcriptional mechanisms. In recent years, understanding of the mechanics of these processes and the contexts in which they are employed during hematopoiesis and immune challenge has increased. An important aspect of this progress is recognition of the importance of RNA-binding proteins and noncoding RNAs. These have roles in the development and function of the immune system and in pathogen life cycles, and they represent an important aspect of intracellular immunity.
伴随发育转变、应激反应和增殖的基因表达的快速变化受到信号介导的转录和转录后机制的协调控制。近年来，人们对这些过程的机制以及在造血和免疫挑战过程中应用这些机制的背景有了更多的了解。这一进展的一个重要方面是认识到 RNA 结合蛋白和非编码 RNA 的重要性。这些在免疫系统的发育和功能以及病原体的生命周期中发挥作用，它们是细胞内免疫的一个重要方面。
