Division of Immunology, Biomedical Sciences Research Center "Alexander Fleming", Vari, Greece.
Nat Immunol. 2014 Jun;15(6):492-502. doi: 10.1038/ni.2884.
Immunological reactions are propelled by ever-changing signals that alter the translational ability of the RNA in the cells involved. Such alterations are considered to be consequential modifications in the transcriptomic decoding of the genetic blueprint. The identification of RNA-binding protein (RBP) assemblies engaged in the coordinative regulation of state-specific RNAs indicates alternative and exclusive means for determining the activation, plasticity and tolerance of cells of the immune system. Here we review current knowledge about RBP-regulated post-transcriptional events involved in the reactivity of cells of the immune system and the importance of their alteration during chronic inflammatory pathology and autoimmunity.
免疫反应是由不断变化的信号推动的，这些信号改变了相关细胞中 RNA 的翻译能力。这种改变被认为是遗传蓝图转录组解码的重要修饰。鉴定参与协调调控特定状态 RNA 的 RNA 结合蛋白 (RBP) 复合物，表明了确定免疫系统细胞的激活、可塑性和耐受性的替代和独特方法。在这里，我们回顾了关于 RBP 调节的转录后事件的最新知识，这些事件涉及免疫系统细胞的反应性，以及它们在慢性炎症病理和自身免疫过程中改变的重要性。
