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胚胎小鼠中，独立呼吸振荡器之间的时间延迟需要Atoh1依赖性菱唇神经元。

Atoh1-dependent rhombic lip neurons are required for temporal delay between independent respiratory oscillators in embryonic mice.

作者信息

Tupal Srinivasan, Huang Wei-Hsiang, Picardo Maria Cristina D, Ling Guang-Yi, Del Negro Christopher A, Zoghbi Huda Y, Gray Paul A

机构信息

Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, United States.

Program in Developmental Biology, Baylor College of Medicine, Houston, United States Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Baylor College of Medicine, Houston, United States.

出版信息

Elife. 2014 May 14;3:e02265. doi: 10.7554/eLife.02265.

DOI:10.7554/eLife.02265
PMID:24842997
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4060005/
Abstract

All motor behaviors require precise temporal coordination of different muscle groups. Breathing, for example, involves the sequential activation of numerous muscles hypothesized to be driven by a primary respiratory oscillator, the preBötzinger Complex, and at least one other as-yet unidentified rhythmogenic population. We tested the roles of Atoh1-, Phox2b-, and Dbx1-derived neurons (three groups that have known roles in respiration) in the generation and coordination of respiratory output. We found that Dbx1-derived neurons are necessary for all respiratory behaviors, whereas independent but coupled respiratory rhythms persist from at least three different motor pools after eliminating or silencing Phox2b- or Atoh1-expressing hindbrain neurons. Without Atoh1 neurons, however, the motor pools become temporally disorganized and coupling between independent respiratory oscillators decreases. We propose Atoh1 neurons tune the sequential activation of independent oscillators essential for the fine control of different muscles during breathing.DOI: http://dx.doi.org/10.7554/eLife.02265.001.

摘要

所有运动行为都需要不同肌肉群进行精确的时间协调。例如，呼吸涉及众多肌肉的顺序激活，据推测这些肌肉由一个主要的呼吸振荡器——前包钦格复合体驱动，并且至少还有一个尚未确定的节律性神经元群。我们测试了源自Atoh1、Phox2b和Dbx1的神经元（已知在呼吸中起作用的三组神经元）在呼吸输出的产生和协调中的作用。我们发现源自Dbx1的神经元对所有呼吸行为都是必需的，而在消除或沉默表达Phox2b或Atoh1的后脑神经元后，至少三个不同运动池仍存在独立但耦合的呼吸节律。然而，没有Atoh1神经元时，运动池在时间上变得紊乱，独立呼吸振荡器之间的耦合减少。我们提出Atoh1神经元调节独立振荡器的顺序激活，这对于呼吸过程中不同肌肉的精细控制至关重要。DOI: http://dx.doi.org/10.7554/eLife.02265.001

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