Reichlmayr-Lais A M, Kirchgessner M
Arch Tierernahr. 1981 Dec;31(11-12):731-7. doi: 10.1080/17450398109425115.
In model studies with rats it was tested whether symptoms of deficiency could be induced if only lead was removed from an optimal composed diet. For this purpose, one growth experiment and one experiment over generations were conducted. In both experiments depletion diets were fed with a lead concentration of 45 +/- 5 ppb, whereas the control diet was supplemented with 1 ppm lead. In the growth experiment there were no differences in weight and hematological criteria between lead-depleted rats and control rats after 30 days. Similarly in the experiment over generation neither the mother p0 nor the young rats of the f1-generation showed changes in growth rate. However, hematological abnormalities could be measured in these rats of the f1-generation at the day of weaning. In comparison with the control rats the lead-depleted rats showed reduced values of Hct by about 11%, Hb by about 15% and MCV by about 9%. Therefore, these experiments demonstrated first physiological abnormalities as the result of lead-depletion, findings which indicate the essentiality of lead.
在对大鼠的模型研究中，测试了如果仅从最佳配方饮食中去除铅，是否会诱发缺乏症状。为此，进行了一项生长实验和一项多代实验。在这两项实验中，给耗尽饮食组喂食铅浓度为45±5 ppb的食物，而对照饮食则补充1 ppm的铅。在生长实验中，30天后，缺铅大鼠和对照大鼠在体重和血液学指标上没有差异。同样，在多代实验中，亲代p0代和f1代幼鼠的生长速率均未显示出变化。然而，在断奶当天，可以测量到这些f1代大鼠存在血液学异常。与对照大鼠相比，缺铅大鼠的红细胞压积值降低了约11%，血红蛋白降低了约15%，平均红细胞体积降低了约9%。因此，这些实验首次证明了缺铅会导致生理异常，这些发现表明铅是必不可少的。
