Cutaneous Leishmaniasis Research Center, Emam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Iran J Basic Med Sci. 2014 Mar;17(3):216-9.
OBJECTIVE(S): In this study, the serum level of interferon-γ (IFN- γ) and interlukin-4 (IL-4) was evaluated as a marker of Th1 and Th2 immune response that influence the clinical course of cutaneous leishmaniasis .
This cross-sectional study was conducted on 44 cases of cutaneous leishmaniasis (21 cases with healed lesions and 23 cases with chronic non-healing lesions. Thirty-two non-infected persons living in the area were considered as controls. Serum levels of IFN- γ and IL-4 were determined using ELISA, and the results along with clinical data were analyzed using SPSS 11.5.
Serum IFN-γ level was not significantly different between various patient groups and control (P=0.27), but the serum level of IL-4 in patient groups was higher than in healthy subjects, and it was higher in patients with non-healed chronic cutaneous leishmaniasis than those with healed lesions (P<0.01).
Serum IL-4 level is a good marker for evaluation of the clinical course of cutaneous leishmaniasis.
本研究通过评估干扰素-γ（IFN-γ）和白细胞介素-4（IL-4）的血清水平，作为影响皮肤利什曼病临床病程的 Th1 和 Th2 免疫反应的标志物。
这是一项横断面研究，共纳入 44 例皮肤利什曼病患者（21 例治愈皮损和 23 例慢性非愈合皮损），并以 32 名生活在该地区的未感染人群作为对照。采用 ELISA 法检测血清 IFN-γ和 IL-4 水平，采用 SPSS 11.5 软件对结果及临床资料进行分析。
不同患者组与对照组的 IFN-γ 血清水平无显著差异（P=0.27），但患者组的 IL-4 血清水平高于健康对照组，且慢性非愈合皮损患者高于治愈皮损患者（P<0.01）。
血清 IL-4 水平是评估皮肤利什曼病临床病程的良好标志物。
