Pomerleau C S, Majchrzak M J, Pomerleau O F
Department of Psychiatry, University of Michigan, Ann Arbor 48105.
J Subst Abuse. 1989;1(4):471-7.
The Fagerström Tolerance Questionnaire (TQ) is widely used in both clinical and research settings as a measure of physiological dependence on nicotine. In the light of claims that the efficacy of nicotine gum is related to degree of dependence and that outcomes can be improved by tailoring gum strength to degree of dependence, the availability of a simple, noninvasive test of dependence assumes additional importance. Recently, a number of articles have expressed reservations about various aspects of the TQ: 1) Several TQ items suffer from flaws or ambiguities that undermine their usefulness, and 2) the TQ may not measure what it purports to measure. The present paper reviews these issues, assembles data and observations that bear on the problems, and makes suggestions that may help in refining the TQ or producing a better instrument.
法格斯特龙耐受性问卷（TQ）在临床和研究环境中都被广泛用作衡量对尼古丁生理依赖程度的工具。鉴于有观点认为尼古丁口香糖的疗效与依赖程度相关，且根据依赖程度调整口香糖强度可改善治疗效果，因此，一种简单、非侵入性的依赖测试就显得尤为重要。最近，有几篇文章对TQ的各个方面表示了保留意见：1）TQ的几个项目存在缺陷或歧义，影响了其效用；2）TQ可能并未测量其声称要测量的内容。本文回顾了这些问题，收集了与这些问题相关的数据和观察结果，并提出了一些建议，可能有助于完善TQ或开发出更好的工具。
