Seedat Y K, Aboo N, Naicker S, Parsoo I
Department of Medicine, University of Natal, Durban, Republic of South Africa.
Ren Fail. 1989;11(4):209-12. doi: 10.3109/08860228909054933.
This study investigated the clinical and biochemical features of acute renal failure in marathon runners. Over a period of 18 years (1969-1986), 19 patients were admitted to the renal unit. The histories and biochemical data of 4 patients seen in 1986 are described. The pathophysiology of acute renal failure is multifactorial and is the combined effect of rhabdomyolysis, dehydration, hypotension, nonsteroidal anti-inflammatory drugs, and hyperuricaemia. Efforts to correct dehydration have resulted in a decrease in the incidence of acute renal failure. The use of nonsteroidal anti-inflammatory drugs is to be deprecated and efforts should be made to publicize this harmful effect.
本研究调查了马拉松运动员急性肾衰竭的临床和生化特征。在18年期间（1969 - 1986年），19名患者入住肾脏科。描述了1986年所见的4例患者的病史和生化数据。急性肾衰竭的病理生理学是多因素的，是横纹肌溶解、脱水、低血压、非甾体抗炎药和高尿酸血症共同作用的结果。纠正脱水的努力已使急性肾衰竭的发病率有所下降。非甾体抗炎药的使用应受到谴责，应努力宣传其有害影响。
