Janevic Teresa, Kahn Linda G, Landsbergis Paul, Cirillo Piera M, Cohn Barbara A, Liu Xinhua, Factor-Litvak Pam
Department of Epidemiology, Rutgers School of Public Health, Rutgers, the State University of New Jersey, New Brunswick, New Jersey.
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York.
Fertil Steril. 2014 Aug;102(2):530-8. doi: 10.1016/j.fertnstert.2014.04.021. Epub 2014 May 23.
To evaluate associations between work-related stress, stressful life events, and perceived stress and semen quality.
Cross-sectional analysis.
Northern California.
PATIENT(S): 193 men from the Child Health and Development Studies evaluated between 2005-2008.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Measures of stress including job strain, perceived stress, and stressful life events; outcome measures of sperm concentration, percentage of motile sperm, and percentage of morphologically normal sperm.
RESULT(S): We found an inverse association between perceived stress score and sperm concentration (estimated coefficient b=-0.09×10(3)/mL; 95% confidence interval [CI]=-0.18, -0.01), motility (b=-0.39; 95% CI=-0.79, 0.01), and morphology (b=-0.14; 95% CI, -0.25, -0.04) in covariate-adjusted linear regression analyses. Men who experienced two or more stressful life events in the past year compared with no stressful events had a lower percentage of motile sperm (b=-8.22; 95% CI, -14.31, -2.13) and a lower percentage of morphologically normal sperm (b=-1.66; 95% CI, -3.35, 0.03) but a similar sperm concentration. Job strain was not associated with semen parameters.
CONCLUSION(S): In this first study to examine all three domains of stress, perceived stress and stressful life events but not work-related stress were associated with semen quality.
评估工作相关压力、生活应激事件和感知压力与精液质量之间的关联。
横断面分析。
北加利福尼亚。
193名来自儿童健康与发展研究的男性，于2005年至2008年期间接受评估。
无。
压力测量指标，包括工作压力、感知压力和生活应激事件；精子浓度、活动精子百分比和形态正常精子百分比等结局指标。
在协变量调整线性回归分析中，我们发现感知压力评分与精子浓度（估计系数b = -0.09×10³/mL；95%置信区间[CI] = -0.18，-0.01）、活动率（b = -0.39；95% CI = -0.79，0.01）和形态（b = -0.14；95% CI，-0.25，-0.04）呈负相关。与无应激事件相比，过去一年经历两次或更多生活应激事件的男性，其活动精子百分比更低（b = -8.22；95% CI，-14.31，-2.13），形态正常精子百分比更低（b = -1.66；95% CI，-3.35，0.03），但精子浓度相似。工作压力与精液参数无关。
在这项首次研究所有三个压力领域的研究中，感知压力和生活应激事件而非工作相关压力与精液质量有关。
