从相似半枝海绵中分离和鉴定抗锥虫和抗分枝杆菌活性甾体。

Isolation and identification of antitrypanosomal and antimycobacterial active steroids from the sponge Haliclona simulans.

作者信息

Viegelmann Christina, Parker Jennifer, Ooi Thengtheng, Clements Carol, Abbott Gráinne, Young Louise, Kennedy Jonathan, Dobson Alan D W, Edrada-Ebel RuAngelie

机构信息

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, The John Arbuthnott Building, 161 Cathedral Street, Glasgow, Scotland G4 0RE, UK.

Marine Biotechnology Centre, Environmental Research Institute, University College Cork, Lee Road, Cork, Ireland.

出版信息

Mar Drugs. 2014 May 16;12(5):2937-52. doi: 10.3390/md12052937.

The marine sponge Haliclona simulans collected from the Irish Sea yielded two new steroids: 24-vinyl-cholest-9-ene-3β,24-diol and 20-methyl-pregn-6-en-3β-ol,5a,8a-epidioxy, along with the widely distributed 24-methylenecholesterol. One of the steroids possesses an unusually short hydrocarbon side chain. The structures were elucidated using nuclear magnetic resonance spectroscopy and confirmed using electron impact- and high resolution electrospray-mass spectrometry. All three steroids possess antitrypanosomal and anti-mycobacterial activity. All the steroids were found to possess low cytotoxicity against Hs27 which was above their detected antitrypanosomal potent concentrations.