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从相似半枝海绵中分离和鉴定抗锥虫和抗分枝杆菌活性甾体。

Isolation and identification of antitrypanosomal and antimycobacterial active steroids from the sponge Haliclona simulans.

作者信息

Viegelmann Christina, Parker Jennifer, Ooi Thengtheng, Clements Carol, Abbott Gráinne, Young Louise, Kennedy Jonathan, Dobson Alan D W, Edrada-Ebel RuAngelie

机构信息

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, The John Arbuthnott Building, 161 Cathedral Street, Glasgow, Scotland G4 0RE, UK.

Marine Biotechnology Centre, Environmental Research Institute, University College Cork, Lee Road, Cork, Ireland.

出版信息

Mar Drugs. 2014 May 16;12(5):2937-52. doi: 10.3390/md12052937.

DOI:10.3390/md12052937
PMID:24862183
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4052325/
Abstract

The marine sponge Haliclona simulans collected from the Irish Sea yielded two new steroids: 24-vinyl-cholest-9-ene-3β,24-diol and 20-methyl-pregn-6-en-3β-ol,5a,8a-epidioxy, along with the widely distributed 24-methylenecholesterol. One of the steroids possesses an unusually short hydrocarbon side chain. The structures were elucidated using nuclear magnetic resonance spectroscopy and confirmed using electron impact- and high resolution electrospray-mass spectrometry. All three steroids possess antitrypanosomal and anti-mycobacterial activity. All the steroids were found to possess low cytotoxicity against Hs27 which was above their detected antitrypanosomal potent concentrations.

摘要

从爱尔兰海采集的海洋海绵模拟Haliclona产生了两种新的甾体：24-乙烯基-胆甾-9-烯-3β,24-二醇和20-甲基-孕甾-6-烯-3β-醇，5α,8α-环氧，以及广泛分布的24-亚甲基胆固醇。其中一种甾体具有异常短的烃侧链。使用核磁共振光谱阐明结构，并使用电子轰击和高分辨率电喷雾质谱进行确认。所有三种甾体都具有抗锥虫和抗分枝杆菌活性。发现所有甾体对Hs27的细胞毒性较低，高于其检测到的抗锥虫有效浓度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ff/4052325/0638775883bc/marinedrugs-12-02937-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ff/4052325/31dd20587d1f/marinedrugs-12-02937-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ff/4052325/6ef3f5859388/marinedrugs-12-02937-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ff/4052325/933a542b8c5e/marinedrugs-12-02937-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ff/4052325/fdaea2914818/marinedrugs-12-02937-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ff/4052325/1e5a865808be/marinedrugs-12-02937-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ff/4052325/0638775883bc/marinedrugs-12-02937-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ff/4052325/31dd20587d1f/marinedrugs-12-02937-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ff/4052325/6ef3f5859388/marinedrugs-12-02937-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ff/4052325/933a542b8c5e/marinedrugs-12-02937-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ff/4052325/fdaea2914818/marinedrugs-12-02937-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ff/4052325/1e5a865808be/marinedrugs-12-02937-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ff/4052325/0638775883bc/marinedrugs-12-02937-g006.jpg

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