Department of Medicine, Weill Cornell Medical College, New York, NY; and.
Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.
Blood. 2014 Jul 10;124(2):184-7. doi: 10.1182/blood-2014-03-562538. Epub 2014 May 27.
Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with reciprocal interactions between tumor growth/metastasis and thrombocytosis/platelet activation. Specific molecular pathways have been identified in which tumors can stimulate platelet production and activation; activated platelets can, in turn, promote tumor growth and metastasis. Taken together, these findings provide exciting new potential targets for therapeutic intervention.
副肿瘤性血小板增多症与许多实体瘤有关，常与生存率降低相关。最近的研究表明，血小板与肿瘤细胞之间可能存在一个致病的反馈环，肿瘤的生长/转移与血小板增多/血小板激活之间存在相互作用。已经确定了肿瘤可以刺激血小板生成和激活的特定分子途径；反过来，激活的血小板可以促进肿瘤的生长和转移。综上所述，这些发现为治疗干预提供了令人兴奋的新潜在靶点。
