Shin Soo-Yong, Kim Woo Sung, Lee Jae-Ho
Department of Biomedical Informatics, Asan Medical Center, Seoul, Korea.
Department of Biomedical Informatics, Asan Medical Center, Seoul, Korea. ; Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Healthc Inform Res. 2014 Apr;20(2):109-16. doi: 10.4258/hir.2014.20.2.109. Epub 2014 Apr 30.
Due to the unique characteristics of clinical data, clinical data warehouses (CDWs) have not been successful so far. Specifically, the use of CDWs for biomedical research has been relatively unsuccessful thus far. The characteristics necessary for the successful implementation and operation of a CDW for biomedical research have not clearly defined yet.
THREE EXAMPLES OF CDWS WERE REVIEWED: a multipurpose CDW in a hospital, a CDW for independent multi-institutional research, and a CDW for research use in an institution. After reviewing the three CDW examples, we propose some key characteristics needed in a CDW for biomedical research.
A CDW for research should include an honest broker system and an Institutional Review Board approval interface to comply with governmental regulations. It should also include a simple query interface, an anonymized data review tool, and a data extraction tool. Also, it should be a biomedical research platform for data repository use as well as data analysis.
The proposed characteristics desired in a CDW may have limited transfer value to organizations in other countries. However, these analysis results are still valid in Korea, and we have developed clinical research data warehouse based on these desiderata.
由于临床数据的独特特性，临床数据仓库（CDW）至今尚未成功。具体而言，到目前为止，CDW在生物医学研究中的应用相对不太成功。用于生物医学研究的CDW成功实施和运行所需的特性尚未明确界定。
回顾了三个CDW实例：一家医院的多用途CDW、一个用于独立多机构研究的CDW以及一个用于机构内研究的CDW。在回顾这三个CDW实例后，我们提出了生物医学研究用CDW所需的一些关键特性。
用于研究的CDW应包括一个诚信中介系统和一个机构审查委员会批准接口，以符合政府规定。它还应包括一个简单的查询接口、一个匿名数据审查工具和一个数据提取工具。此外，它应是一个用于数据存储库使用以及数据分析的生物医学研究平台。
CDW中所期望的这些特性对其他国家的组织可能具有有限的转移价值。然而，这些分析结果在韩国仍然有效，并且我们已基于这些需求开发了临床研究数据仓库。
