Ting J, Rositch A F, Taylor S M, Rahangdale L, Soeters H M, Sun X, Smith J S
Department of Clinical Pharmacy,University of California,San Francisco, CA,USA.
Department of Epidemiology,Johns Hopkins Bloomberg School of Public Health,Baltimore, MD,USA.
Epidemiol Infect. 2015 Jan;143(2):225-41. doi: 10.1017/S0950268814001356. Epub 2014 May 30.
We conducted a systematic review summarizing data on incidence of high- and low-grade lesions in women with normal baseline cervical cytology, stratified by age (<30 and ⩾30 years), and baseline human papillomavirus (HPV) infection. Incidence of high- and low-grade lesions in women aged ⩾30 years with a baseline HPV infection increased over follow-up time (5-127 months), although incidence generally remained <10%. Without baseline HPV infection, incidence of high-grade lesions remained low over follow-up time (<5% over 5-122 months). Incidence of high-grade lesions in women aged ⩾30 years with baseline HPV infection appeared similar to that in women aged <30 years. In some women aged <30 years, high-grade lesions can develop relatively shortly after initial HPV infection. We observed an increase in low-grade lesions over time in women aged ⩾30 years with baseline HPV infection, potentially indicative of an HPV infection that is potentially progressing to higher grade lesions.
我们进行了一项系统综述，总结了基线宫颈细胞学检查正常的女性中高级别和低级别病变的发生率数据，并按年龄（<30岁和⩾30岁）以及基线人乳头瘤病毒（HPV）感染情况进行分层。在随访时间（5 - 127个月）内，基线HPV感染的30岁及以上女性中高级别和低级别病变的发生率有所增加，尽管发生率总体仍<10%。在无基线HPV感染的情况下，高级别病变的发生率在随访期间保持较低水平（5 - 122个月内<5%）。基线HPV感染的30岁及以上女性中高级别病变的发生率似乎与<30岁女性相似。在一些<30岁的女性中，高级别病变可能在初次HPV感染后相对较短的时间内发生。我们观察到基线HPV感染的30岁及以上女性中低级别病变随时间增加，这可能表明HPV感染有进展为更高级别病变的潜在趋势。
