Himuro H, Murata T, Tamesue A, Nakajima T, Hiratsuka M, Tsubaki T, Aono K
Fukuoka Shika Daigaku Gakkai Zasshi. 1989;16(2):323-7.
This study is a pilot study to determine the desirable epinephrine concentration containing in dental local anesthetics. Two percent lidocaine solution containing 1/80,000 and 1/200,000 epinephrine were compared in view points of onset and duration of anesthesia and hemodynamic responses after conduction and infiltration anesthesia in oral cavities of six voluntary dental students. Conduction anesthesia to the right inferior alveolar nerve, using 2% lidocaine solution containing 1/80,000 and 1/200,000 epinephrine showed no significant difference in onset and duration of anesthesia, changes in blood pressure and pulse rate. Duration of anesthesia determined by pin prick showed the longest in infiltration anesthesia, using 2% lidocaine solution containing 1/80,000 epinephrine, (103.4 +/- 18.5 min.), and followed by that containing 1/200,000 epinephrine (52.0 +/- 13.0 min.) and that excluding epinephrine (23.0 +/- 5.1 min.). These findings suggested that the desirable epinephrine concentration containing in dental local anesthetics may be 1/200,000, judging from the time of a dental practice.
本研究是一项初步研究，旨在确定牙科局部麻醉剂中理想的肾上腺素浓度。从麻醉起效时间、持续时间以及六名牙科专业志愿学生口腔传导麻醉和浸润麻醉后的血流动力学反应等方面，对含1/80,000和1/200,000肾上腺素的2%利多卡因溶液进行了比较。对右下牙槽神经进行传导麻醉时，使用含1/80,000和1/200,000肾上腺素的2%利多卡因溶液，在麻醉起效时间、持续时间、血压和脉搏率变化方面均无显著差异。通过针刺确定的麻醉持续时间，在使用含1/80,000肾上腺素的2%利多卡因溶液进行浸润麻醉时最长（103.4 +/- 18.5分钟），其次是含1/200,000肾上腺素的溶液（52.0 +/- 13.0分钟），不含肾上腺素的溶液最短（23.0 +/- 5.1分钟）。从牙科实际操作时间来看，这些结果表明牙科局部麻醉剂中理想的肾上腺素浓度可能为1/200,000。
