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The synergistic effect of a hybrid graphene oxide-chitosan system and biomimetic mineralization on osteoblast functions.氧化石墨烯-壳聚糖混合体系与仿生矿化对成骨细胞功能的协同作用。
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Synthesis of hydroxyapatite-reduced graphite oxide nanocomposites for biomedical applications: oriented nucleation and epitaxial growth of hydroxyapatite.用于生物医学应用的羟基磷灰石-还原氧化石墨烯纳米复合材料的合成：羟基磷灰石的取向成核和外延生长
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In situ synthesis and biocompatibility of nano hydroxyapatite on pristine and chitosan functionalized graphene oxide.纳米羟基磷灰石在原始及壳聚糖功能化氧化石墨烯上的原位合成及其生物相容性
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Is graphene a promising nano-material for promoting surface modification of implants or scaffold materials in bone tissue engineering?石墨烯是用于促进骨组织工程中植入物或支架材料表面改性的一种有前景的纳米材料吗？
Tissue Eng Part B Rev. 2014 Oct;20(5):477-91. doi: 10.1089/ten.TEB.2013.0638. Epub 2014 Feb 27.
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Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation.核层粘连蛋白 A 与组织硬度成正比，并增强基质导向的分化。
Science. 2013 Aug 30;341(6149):1240104. doi: 10.1126/science.1240104.
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Graphene-regulated cardiomyogenic differentiation process of mesenchymal stem cells by enhancing the expression of extracellular matrix proteins and cell signaling molecules.石墨烯通过增强细胞外基质蛋白和细胞信号分子的表达来调控间充质干细胞的心肌生成分化过程。
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Calcium phosphate ceramics in bone tissue engineering: a review of properties and their influence on cell behavior.钙磷酸盐陶瓷在骨组织工程中的应用：性质及其对细胞行为影响的综述。
Acta Biomater. 2013 Sep;9(9):8037-45. doi: 10.1016/j.actbio.2013.06.014. Epub 2013 Jun 19.
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Mechanobiology of bone marrow stem cells: from myosin-II forces to compliance of matrix and nucleus in cell forms and fates.骨髓干细胞的机械生物学：从肌球蛋白 II 力到基质和核的顺应性，在细胞形态和命运中。
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Bioactive effects of graphene oxide cell culture substratum on structure and function of human adipose-derived stem cells.氧化石墨烯细胞培养基质对人脂肪来源干细胞结构和功能的生物活性影响。
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Interplay between myosin IIA-mediated contractility and actin network integrity orchestrates podosome composition and oscillations.肌球蛋白 IIA 介导的收缩性与肌动蛋白网络完整性之间的相互作用协调了足状伪足的组成和振荡。
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氧化石墨烯-磷酸钙纳米复合材料协同加速人骨髓间充质干细胞的成骨作用

Synergistic acceleration in the osteogenesis of human mesenchymal stem cells by graphene oxide-calcium phosphate nanocomposites.

作者信息

Tatavarty Rameshwar, Ding Hao, Lu Guijin, Taylor Robert J, Bi Xiaohong

机构信息

Department of Nanomedicine and Biomedical Engineering, the University of Texas Health Science Center at Houston, 1881 East Road, Houston, TX 77054, USA.

出版信息

Chem Commun (Camb). 2014 Aug 11;50(62):8484-7. doi: 10.1039/c4cc02442g.

DOI:10.1039/c4cc02442g
PMID:24891127
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4090284/
Abstract

Nanocomposites consisting of oblong ultrathin plate shaped calcium phosphate nanoparticles and graphene oxide microflakes were synthesized and have demonstrated markedly synergistic effect in accelerating stem cell differentiation to osteoblasts.

摘要

由长方形超薄片状磷酸钙纳米颗粒和氧化石墨烯微片组成的纳米复合材料被合成出来，并已证明在加速干细胞向成骨细胞分化方面具有显著的协同作用。