Central Research Laboratory, Bashkir State Medical University, 450000, Ufa, Russia.
State-financed Institution of the Republic of Bashkortostan Environmental Research and Protection Center, 450075, Ufa, Russia.
Environ Sci Pollut Res Int. 2015 Oct;22(19):14566-9. doi: 10.1007/s11356-014-3109-z. Epub 2014 Jun 5.
The purpose of the present study was to assess ejaculate contamination by polychlorinated dibenzo-p-dioxins/furans in male infertility. The database of 168 infertile and 49 fertile men was included in the study. Dioxin content was determined using gas chromatography/high-resolution mass spectrometry (GC/HRMS). In the ejaculate of infertile men, the content of dioxins and furans was 2.2-2.3 times higher than in fertile donors. The maximum level of the most toxic dioxin congener was detected in pathospermia. Contamination of semen of infertile men by polychlorinated dibenzo-p-dioxins/furans supports the hypothesis about the relationship between environmental factors and reproductive health.
本研究旨在评估男性不育症患者精液中二恶英/呋喃的污染情况。研究纳入了 168 名不育男性和 49 名正常生育男性的数据库。二恶英含量采用气相色谱/高分辨率质谱法（GC/HRMS）进行测定。在不育男性的精液中，二恶英和呋喃的含量比正常生育男性高 2.2-2.3 倍。在精子质量差的患者精液中，检测到了毒性最强的二恶英同系物的最高水平。不育男性精液中二恶英/呋喃的污染支持了环境因素与生殖健康之间存在关系的假说。
