Pawlowski Jessica W, Martin Berdine R, McCabe George P, Ferruzzi Mario G, Weaver Connie M
Department of Nutrition Science, College of Health and Human Sciences, Purdue University , 700 West State Street, West Lafayette, Indiana 47907, United States.
J Agric Food Chem. 2014 Jul 2;62(26):6108-17. doi: 10.1021/jf403310q. Epub 2014 Jun 19.
Plant-derived polyphenols have been shown to influence bone turnover and bone properties in the estrogen-depleted state. We used a crossover design in ovariectomized rats (n = 16 rats for each diet) to investigate the effect of supplementation of two doses each of blueberry, plum, grape, grape seed extract, and resveratrol on bone. We tested the aglycon and glucoside forms of genistein to quantify differences in efficacy on bone calcium retention. Rats were given an intravenous dose of ⁴⁵Ca to prelabel bone, and bone calcium retention was assessed by urinary excretion of ⁴⁵Ca:Ca ratio during an intervention period compared with nonintervention. Genistein aglycon increased bone calcium retention significantly (p<0.05) more than the glucoside (22% vs 13%, respectively). Plum extract (0.45% w/w total dietary polyphenols) and resveratrol (0.2% w/w total dietary polyphenols) were also effective, increasing bone calcium retention by 20% (p=0.0153) and 14% (p=0.0012), respectively. Several polyphenolic-rich diets improved bone calcium retention.
植物来源的多酚已被证明在雌激素缺乏状态下会影响骨转换和骨骼特性。我们采用交叉设计，对去卵巢大鼠（每种饮食16只大鼠）进行研究，以探讨蓝莓、李子、葡萄、葡萄籽提取物和白藜芦醇各两种剂量的补充对骨骼的影响。我们测试了染料木黄酮的苷元形式和糖苷形式，以量化对骨钙保留功效的差异。给大鼠静脉注射⁴⁵Ca对骨骼进行预标记，并通过干预期内⁴⁵Ca:Ca的尿排泄量与非干预期相比来评估骨钙保留情况。染料木黄酮苷元比糖苷更显著地增加了骨钙保留（分别为22%对13%，p<0.05）。李子提取物（总膳食多酚含量为0.45% w/w）和白藜芦醇（总膳食多酚含量为0.2% w/w）也有效，分别使骨钙保留增加了20%（p=0.0153）和14%（p=0.0012）。几种富含多酚的饮食改善了骨钙保留。
