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荜茇酰胺可诱导人卵巢癌细胞凋亡，并与顺铂或紫杉醇协同作用。

Piperlongumine induces apoptosis and synergizes with cisplatin or paclitaxel in human ovarian cancer cells.

作者信息

Gong Li-Hua, Chen Xiu-Xiu, Wang Huan, Jiang Qi-Wei, Pan Shi-Shi, Qiu Jian-Ge, Mei Xiao-Long, Xue You-Qiu, Qin Wu-Ming, Zheng Fei-Yun, Shi Zhi, Yan Xiao-Jian

机构信息

Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical College, Shangcai Village South, Ouhai District, Wenzhou, Zhejiang 325000, China.

Department of Gynecology, The Third Affiliated Hospital of Sun-Yat Sen University, Guangzhou, Guangdong 510632, China.

出版信息

Oxid Med Cell Longev. 2014;2014:906804. doi: 10.1155/2014/906804. Epub 2014 May 8.

DOI:10.1155/2014/906804
PMID:24895529
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4034765/
Abstract

Piperlongumine (PL), a natural alkaloid from Piper longum L., possesses the highly selective and effective anticancer property. However, the effect of PL on ovarian cancer cells is still unknown. In this study, we firstly demonstrate that PL selectively inhibited cell growth of human ovarian cancer cells. Furthermore, PL notably induced cell apoptosis, G2/M phase arrest, and accumulation of the intracellular reactive oxidative species (ROS) in a dose- and time-dependent manner. Pretreatment with antioxidant N-acety-L-cysteine could totally reverse the PL-induced ROS accumulation and cell apoptosis. In addition, low dose of PL/cisplatin or paclitaxel combination therapies had a synergistic antigrowth effect on human ovarian cancer cells. Collectively, our study provides new therapeutic potential of PL on human ovarian cancer.

摘要

胡椒碱（PL）是一种来自荜茇的天然生物碱，具有高度选择性和有效的抗癌特性。然而，PL对卵巢癌细胞的作用仍不清楚。在本研究中，我们首先证明PL能选择性抑制人卵巢癌细胞的生长。此外，PL能显著诱导细胞凋亡、G2/M期阻滞，并以剂量和时间依赖性方式诱导细胞内活性氧（ROS）的积累。用抗氧化剂N-乙酰-L-半胱氨酸预处理可完全逆转PL诱导的ROS积累和细胞凋亡。此外，低剂量的PL/顺铂或紫杉醇联合疗法对人卵巢癌细胞具有协同抗生长作用。总之，我们的研究为PL在人卵巢癌治疗方面提供了新的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fb/4034765/11e11adc7bc6/OMCL2014-906804.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fb/4034765/68efc34af50d/OMCL2014-906804.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fb/4034765/1a33329e99d2/OMCL2014-906804.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fb/4034765/699381846abf/OMCL2014-906804.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fb/4034765/7714ae255a63/OMCL2014-906804.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fb/4034765/cd6c1620d7c8/OMCL2014-906804.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fb/4034765/f2312594cde2/OMCL2014-906804.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fb/4034765/11e11adc7bc6/OMCL2014-906804.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fb/4034765/68efc34af50d/OMCL2014-906804.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fb/4034765/1a33329e99d2/OMCL2014-906804.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fb/4034765/699381846abf/OMCL2014-906804.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fb/4034765/7714ae255a63/OMCL2014-906804.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fb/4034765/cd6c1620d7c8/OMCL2014-906804.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fb/4034765/f2312594cde2/OMCL2014-906804.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fb/4034765/11e11adc7bc6/OMCL2014-906804.007.jpg

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