Hvas Anne-Mette, Grove Erik Lerkevang
Aarhus University Hospital, Palle Juul Jensens Boulevard 99, 8200, Aarhus N, Denmark.
Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Methods Mol Biol. 2017;1646:305-320. doi: 10.1007/978-1-4939-7196-1_24.
Platelet function tests are mainly used in the diagnostic work-up of platelet disorders. During the last decade, the additional use of platelet function tests to evaluate the effect of antiplatelet therapy has also emerged in an attempt to identify patients with an increased risk of arterial thrombosis. Furthermore, platelet function tests are increasingly used to measure residual effect of antiplatelet therapy prior to surgery with the aim of reducing the risk of bleeding. To a limited extend, platelet function tests are also used to evaluate hyperaggregability as a potential marker of a prothrombotic state outside the setting of antiplatelet therapy. This multifaceted use of platelet function tests and the development of simpler point-of-care tests with narrower application have increased the use of platelet function testing and also facilitated the use of platelet function tests outside the highly specialized laboratories. The present chapter describes the preanalytical variables, which should be taken into account when planning platelet function testing. Also, the most widely used platelet function tests are introduced, and their clinical utility and their relative advantages and disadvantages are discussed.
血小板功能检测主要用于血小板疾病的诊断检查。在过去十年中，血小板功能检测还被额外用于评估抗血小板治疗的效果，以试图识别动脉血栓形成风险增加的患者。此外，血小板功能检测越来越多地用于在手术前测量抗血小板治疗的残余效果，目的是降低出血风险。在有限的范围内，血小板功能检测也用于评估高聚集性，作为抗血小板治疗背景之外血栓前状态的潜在标志物。血小板功能检测的这种多方面应用以及应用范围更窄的更简单即时检测方法的发展，增加了血小板功能检测的使用，也促进了在高度专业化实验室之外使用血小板功能检测。本章描述了在计划血小板功能检测时应考虑的分析前变量。此外，还介绍了最广泛使用的血小板功能检测方法，并讨论了它们的临床实用性以及相对优缺点。
