对 S100A8/A9 在皮肤生物学中作用的新认识。
Novel insights into the role of S100A8/A9 in skin biology.
机构信息
Fraunhofer Institute for Cell Therapy and Immunology, Department of Immunology, AG EXIM, Rostock, Germany.
出版信息
Exp Dermatol. 2012 Nov;21(11):822-6. doi: 10.1111/j.1600-0625.2012.01571.x. Epub 2012 Aug 9.
Abstract
S100A8 and S100A9 belong to the damage-associated molecular pattern molecules. They are upregulated in a number of inflammatory skin disorders. Owing to their abundance in myeloid cells, the main function of S100A8/A9 has been attributed to their role in inflammatory cells. However, it is becoming increasingly clear that they also exert important roles in epithelial cells. In this review, we discuss the context-dependent function of S100A8/A9 in epithelial cells and their impact on wound healing, psoriasis and other skin diseases.
摘要
S100A8 和 S100A9 属于损伤相关分子模式分子。它们在许多炎症性皮肤病中上调。由于它们在髓样细胞中丰富，S100A8/A9 的主要功能归因于它们在炎症细胞中的作用。然而，越来越明显的是，它们在上皮细胞中也发挥着重要作用。在这篇综述中，我们讨论了 S100A8/A9 在上皮细胞中的上下文相关功能及其对伤口愈合、银屑病和其他皮肤病的影响。
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本文引用的文献
1
Double-stranded RNA induces S100 gene expression by a cycloheximide-sensitive factor.
FEBS Lett. 2012 Jan 20;586(2):196-203. doi: 10.1016/j.febslet.2011.12.022. Epub 2011 Dec 29.
2
Loss of myeloid related protein-8/14 exacerbates cardiac allograft rejection.
Circulation. 2011 Dec 20;124(25):2920-32. doi: 10.1161/CIRCULATIONAHA.110.009910. Epub 2011 Dec 5.
3
The effect of pimecrolimus on expression of genes associated with skin barrier dysfunction in atopic dermatitis skin lesions.
Exp Dermatol. 2012 Mar;21(3):184-8. doi: 10.1111/j.1600-0625.2011.01417.x. Epub 2011 Dec 6.
4
Protein synthesis of the pro-inflammatory S100A8/A9 complex in plasmacytoid dendritic cells and cell surface S100A8/A9 on leukocyte subpopulations in systemic lupus erythematosus.
Arthritis Res Ther. 2011 Apr 14;13(2):R60. doi: 10.1186/ar3314.
5
S100A9 differentially modifies phenotypic states of neutrophils, macrophages, and dendritic cells: implications for atherosclerosis and adipose tissue inflammation.
Circulation. 2011 Mar 22;123(11):1216-26. doi: 10.1161/CIRCULATIONAHA.110.985523. Epub 2011 Mar 7.
6
Damage-associated molecular pattern S100A9 increases bactericidal activity of human neutrophils by enhancing phagocytosis.
J Immunol. 2011 Mar 15;186(6):3622-31. doi: 10.4049/jimmunol.1002956. Epub 2011 Feb 16.
7
Expression of S100A8/A9 in HaCaT keratinocytes alters the rate of cell proliferation and differentiation.
FEBS Lett. 2011 Jan 21;585(2):440-6. doi: 10.1016/j.febslet.2010.12.037. Epub 2010 Dec 28.
8
Epithelial-mesenchymal transition in the skin.
J Dermatol Sci. 2011 Jan;61(1):7-13. doi: 10.1016/j.jdermsci.2010.11.015. Epub 2010 Dec 5.
9
Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons.
J Exp Med. 2010 Dec 20;207(13):2921-30. doi: 10.1084/jem.20101102. Epub 2010 Nov 29.
10
Differential proteomic analysis distinguishes tissue repair biomarker signatures in wound exudates obtained from normal healing and chronic wounds.
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