From The Daroff-Dell'Osso Laboratory (A.S., M.M.S., J.B.J., M.F.W.), Louis Stokes Veterans Affairs Medical Center; University Hospitals (A.S.); Case Western Reserve University (A.S., J.B.J., M.F.W.); and the Mellen Center for Multiple Sclerosis Treatment and Research (J.A.C.), Neurological Institute, Cleveland Clinic, Cleveland, OH.
Neurology. 2014 Jul 8;83(2):192-4. doi: 10.1212/WNL.0000000000000567. Epub 2014 Jun 6.
Internuclear ophthalmoparesis (INO) in multiple sclerosis (MS) is due to demyelination of the medial longitudinal fasciculus (MLF) and provides an accessible model for studying consequences of raised body temperature and fatigue on central demyelination. Prompted by one of our patient’s report of vision improvement after initiating dalfampridine, a potassium channel blocker prescribed for gait impairment, we measured this drug's effects on 3 patients with MS with bilateral INO. All showed changes in horizontal saccadic conjugacy consistent with improved transmission of the neural pulse responsible for adducting movements.
多发性硬化症（MS）中的核间眼肌麻痹（INO）是由于内侧纵束（MLF）的脱髓鞘引起的，为研究体温升高和疲劳对中枢脱髓鞘的影响提供了一个可及的模型。我们的一位患者报告称，在开始使用 dalfampridine（一种用于改善步态障碍的钾通道阻滞剂）后，视力有所改善，这促使我们测量了这种药物对 3 名患有双侧 INO 的 MS 患者的影响。所有患者的水平扫视共轭均发生变化，这与负责内收运动的神经脉冲的传导改善一致。
