State Key Lab of Urban Water Resource and Environment (HIT), Micro/Nanotechnology Research Centre, Harbin Institute of Technology , Harbin 150080, China.
ACS Appl Mater Interfaces. 2014 Jul 9;6(13):10476-81. doi: 10.1021/am502458h. Epub 2014 Jun 16.
We present herein a novel hybrid, polymer-based motor that was fabricated by the template-assisted polyelectrolyte layer-by-layer (LbL) deposition of a thin gold layer on one side, followed by chemical immobilization of a catalytic enzyme. Such Janus capsule motors can self-propel at 0.1% peroxide fuel concentration at physiological temperature and have a higher speed as compared to Pt-based synthetic motors. They were exploited for encapsulation of the chemotherapeutic anticancer drug, doxorubicin, for navigation to target a cell layer by an external magnetic field, and for triggered drug release activated by NIR light. This work provides high potential in the development of multifunctional polymer-based engines for biomedical applications such as targeted drug delivery.
我们在此提出了一种新型的混合聚合物基马达，它是通过在一侧模板辅助的聚电解质层层（LbL）沉积薄金层，然后化学固定催化酶来制备的。这种胶囊马达可以在生理温度下以 0.1%的过氧化物燃料浓度自行推进，并且速度比基于 Pt 的合成马达更快。它们被用于封装化疗抗癌药物阿霉素，通过外部磁场导航到目标细胞层，并通过近红外光触发药物释放。这项工作为开发用于生物医学应用的多功能聚合物基发动机提供了巨大的潜力，例如靶向药物输送。
