Jepson Lauren H, Hottowy Pawel, Weiner Geoffrey A, Dabrowski Władysław, Litke Alan M, Chichilnisky E J
Systems Neurobiology Laboratories, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Bioengineering Department, University of California, San Diego, La Jolla, CA 92093, USA.
AGH University of Science and Technology, Faculty of Physics and Applied Computer Science, 30-059 Krakow, Poland.
Neuron. 2014 Jul 2;83(1):87-92. doi: 10.1016/j.neuron.2014.04.044. Epub 2014 Jun 5.
Natural vision relies on spatiotemporal patterns of electrical activity in the retina. We investigated the feasibility of veridically reproducing such patterns with epiretinal prostheses. Multielectrode recordings and visual and electrical stimulation were performed on populations of identified ganglion cells in isolated peripheral primate retina. Electrical stimulation patterns were designed to reproduce recorded waves of activity elicited by a moving visual stimulus. Electrical responses in populations of ON parasol cells exhibited high spatial and temporal precision, matching or exceeding the precision of visual responses measured in the same cells. Computational readout of electrical and visual responses produced similar estimates of stimulus speed, confirming the fidelity of electrical stimulation for biologically relevant visual signals. These results suggest the possibility of producing rich spatiotemporal patterns of retinal activity with a prosthesis and that temporal multiplexing may aid in reproducing the neural code of the retina.
自然视觉依赖于视网膜中电活动的时空模式。我们研究了使用视网膜外假体准确再现此类模式的可行性。对分离的灵长类动物外周视网膜中已识别的神经节细胞群体进行了多电极记录以及视觉和电刺激。设计电刺激模式以再现由移动视觉刺激引发的记录活动波。ON 伞状细胞群体中的电反应表现出高空间和时间精度，与在相同细胞中测量的视觉反应精度相匹配或超过该精度。对电反应和视觉反应的计算读出产生了相似的刺激速度估计值，证实了电刺激对生物学相关视觉信号的保真度。这些结果表明，使用假体产生丰富的视网膜活动时空模式是可能的，并且时间复用可能有助于再现视网膜的神经编码。
