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纠正我们科学基础设施中的系统性缺陷。

Correcting systemic deficiencies in our scientific infrastructure.

机构信息

Fox Chase Cancer Center.

出版信息

Dose Response. 2013 Dec 6;12(2):185-201. doi: 10.2203/dose-response.13-046.Doss. eCollection 2014 May.

Abstract

Scientific method is inherently self-correcting. When different hypotheses are proposed, their study would result in the rejection of the invalid ones. If the study of a competing hypothesis is prevented because of the faith in an unverified one, scientific progress is stalled. This has happened in the study of low dose radiation. Though radiation hormesis was hypothesized to reduce cancers in 1980, it could not be studied in humans because of the faith in the unverified linear no-threshold model hypothesis, likely resulting in over 15 million preventable cancer deaths worldwide during the past two decades, since evidence has accumulated supporting the validity of the phenomenon of radiation hormesis. Since our society has been guided by scientific advisory committees that ostensibly follow the scientific method, the long duration of such large casualties is indicative of systemic deficiencies in the infrastructure that has evolved in our society for the application of science. Some of these deficiencies have been identified in a few elements of the scientific infrastructure, and remedial steps suggested. Identifying and correcting such deficiencies may prevent similar tolls in the future.

摘要

科学方法本质上是自我修正的。当提出不同的假设时,通过研究就会排除无效的假设。如果由于对未经证实的假设的盲目信任而阻止对竞争性假设的研究,那么科学就会停滞不前。这种情况在低剂量辐射的研究中发生了。尽管在 1980 年就假设辐射兴奋效应会降低癌症发病率,但由于对未经证实的线性无阈假说的盲目信任,这个假设在人类身上无法进行研究,这可能导致过去二十年来全球有超过 1500 万人本可以预防的癌症死亡,因为越来越多的证据支持辐射兴奋效应现象的有效性。由于我们的社会受到表面上遵循科学方法的科学顾问委员会的指导,这种长时间的大量伤亡表明,我们社会在应用科学方面的基础设施存在系统性缺陷。在科学基础设施的一些要素中已经确定了这些缺陷,并提出了补救措施。确定和纠正这些缺陷可能会防止未来出现类似的伤亡。

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本文引用的文献

1
Low dose radiation adaptive protection to control neurodegenerative diseases.低剂量辐射适应性保护控制神经退行性疾病。
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2
Linear No-Threshold Model VS. Radiation Hormesis.线性无阈模型与辐射兴奋效应。
Dose Response. 2013 May 24;11(4):480-97. doi: 10.2203/dose-response.13-005.Doss. eCollection 2013.
10
Energy and human health.能源与人类健康。
Annu Rev Public Health. 2013;34:159-88. doi: 10.1146/annurev-publhealth-031912-114404. Epub 2013 Jan 16.

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