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Toxicol Lett. 2014 Oct 15;230(2):139-45. doi: 10.1016/j.toxlet.2013.10.015. Epub 2013 Oct 25.
2
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Organohalogenated contaminants (OHCs) in human serum of mothers and children from Pakistan with urban and rural residential settings.巴基斯坦城乡居住环境下母婴血清中的有机卤污染物（OHCs）
Sci Total Environ. 2013 Sep 1;461-462:655-62. doi: 10.1016/j.scitotenv.2013.05.044. Epub 2013 Jun 12.
4
Maternal body mass index and the association between folic acid supplements and neural tube defects.母体体重指数与叶酸补充剂和神经管缺陷之间的关联。
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5
Distribution and sources of organochlorine pesticides in agricultural soils from central China.中国中部农业土壤中有机氯农药的分布及来源。
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Maternal overweight and obesity and the risk of neural tube defects: a case-control study in China.孕妇超重与肥胖及神经管缺陷风险：一项中国的病例对照研究
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8
The continuing challenge of understanding, preventing, and treating neural tube defects.神经管缺陷的理解、预防和治疗面临的持续挑战。
Science. 2013 Mar 1;339(6123):1222002. doi: 10.1126/science.1222002.
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Concentrations of organochlorine pesticides (OCPs) in human blood plasma from Hong Kong: markers of exposure and sources from fish.香港人体血浆中有机氯农药 (OCPs) 的浓度：来自鱼类的暴露标志物和来源。
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Route-specific daily uptake of organochlorine pesticides in food, dust, and air by Shanghai residents, China.中国上海居民食物、灰尘和空气中有机氯农药的特定路线日摄入量。
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中国山西省孕妇血清中有机氯农药水平与后代神经管缺陷风险：一项病例对照研究

Organochlorine pesticide levels in maternal serum and risk of neural tube defects in offspring in Shanxi Province, China: a case-control study.

作者信息

Wang Bin, Yi Deqing, Jin Lei, Li Zhiwen, Liu Jufen, Zhang Yali, Qiu Xinghua, Liu Wenxin, Tao Shu, Ren Aiguo

机构信息

Institute of Reproductive and Child Health/Ministry of Health Key Laboratory of Reproductive Health, School of Public Health, Peking University, Beijing 100191, PR China.

State Key Joint Laboratory for Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering and Center for Environment and Health, Peking University, Beijing 100871, PR China.

出版信息

Sci Total Environ. 2014 Aug 15;490:1037-43. doi: 10.1016/j.scitotenv.2014.05.075. Epub 2014 Jun 7.

DOI:10.1016/j.scitotenv.2014.05.075
PMID:24911776
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4133271/
Abstract

UNLABELLED

Organochlorine pesticides (OCPs) in placental tissue have been reported to be associated with an increased risk for fetal neural tube defects (NTDs). Our case-control study was performed to explore the association between maternal serum OCP concentration and NTD risk in offspring. Serum samples were collected from 117 mothers who delivered NTD infants (case group) and 121 mothers who delivered healthy infants (control group). Only three of the 25 OCPs were detected in more than half of the maternal serum samples. The median concentration of total OCPs in the case group was significantly higher than that of the control group. However, no dose-response relationships between higher levels of any individual OCPs or total OCPs and the risk of NTDs or subtypes were observed in either the unadjusted binary unconditional logistic regression model or the model adjusted by potential confounders. We conclude that no clear association between maternal serum OCP residues and NTD risk in offspring was observed in this population.

CAPSULE

No clear association between maternal serum levels of organochlorine pesticides and risk of neural tube defects in offspring was observed for a Chinese population.

摘要

未标注

据报道，胎盘组织中的有机氯农药（OCPs）与胎儿神经管缺陷（NTDs）风险增加有关。我们进行了病例对照研究，以探讨母体血清中OCP浓度与后代NTD风险之间的关联。从117名分娩NTD婴儿的母亲（病例组）和121名分娩健康婴儿的母亲（对照组）中采集血清样本。在超过一半的母体血清样本中仅检测到25种OCP中的3种。病例组中总OCP的中位数浓度显著高于对照组。然而，在未调整的二元无条件逻辑回归模型或由潜在混杂因素调整的模型中，均未观察到任何个体OCP或总OCP水平升高与NTDs或其亚型风险之间的剂量反应关系。我们得出结论，在该人群中未观察到母体血清OCP残留与后代NTD风险之间存在明确关联。

总结

对于中国人群，未观察到母体血清中有机氯农药水平与后代神经管缺陷风险之间存在明确关联。