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响应面法优化头花蓼中槲皮苷和总黄酮的提取工艺

Optimization of quercitrin and total flavonoids extraction from Herba Polygoni Capitati by response surface methodology.

作者信息

Ma Fengwei, Zhao Yang, Gong Xiaojian, Xie Yu, Zhou Xin

机构信息

The Research Center for Quality Control of Nature Medicine, Guizhou Nomal University, Guiyang, Guizhou, P.R. China ; Key Laboratory for Information System of Mountainous Area and Protection of Ecological Environment of Guizhou province, Guizhou Nomal University, Guiyang, Guizhou, P.R. China.

Guizhou Warmen Pharmaceutical Co., Ltd., Guiyang, Guizhou, P.R. China.

出版信息

Pharmacogn Mag. 2014 Jan;10(Suppl 1):S57-64. doi: 10.4103/0973-1296.127343.

DOI:10.4103/0973-1296.127343
PMID:24914309
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4047582/
Abstract

OBJECTIVE

To optimize the conditions for extraction of quercitrin and total flavonoids (TF) from Herba Polygoni Capitati (Touhualiao in Chinese) by using response surface methodology (RSM).

MATERIALS AND METHODS

A central composite design (CCD) was adopted to investigate the effects of three independent variables including solvent composition (%), solvent-material ratio (ml/g) and extraction time (min) on the responses, quercitrin and TF yields.

RESULTS

THE OPTIMIZED CONDITIONS OF THE EXTRACTION ARE AS FOLLOWS: Ethanol concentration, 65.63%; solvent-material ratio, 10.55:1 (ml/g); extraction time, 54.33 min. The established mathematical model described the factors of experimental parameters well and provided a statistically accurate prediction of the optimum yields of quercitrin and TF.

CONCLUSION

The experimental values agreed with those predicted by the established mathematical model, thus indicating the suitability of the model employed and the success of RSM in optimizing the extraction conditions.

摘要

目的

采用响应面法（RSM）优化头花蓼中槲皮苷和总黄酮（TF）的提取条件。

材料与方法

采用中心复合设计（CCD）考察溶剂组成（%）、料液比（ml/g）和提取时间（min）3个自变量对槲皮苷和TF得率响应值的影响。

结果

最佳提取条件如下：乙醇浓度65.63%；料液比10.55∶1（ml/g）；提取时间54.33 min。所建立的数学模型能很好地描述实验参数因素，并对槲皮苷和TF的最佳得率提供了统计学上准确的预测。

结论

实验值与所建立数学模型的预测值相符，表明所采用模型的适用性以及响应面法在优化提取条件方面的成功。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca70/4047582/9f8b64a1ab0d/PM-10-57-g013.jpg
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