1 The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Medical Institutions, 601 North Wolfe Street, Baltimore, MD 21287, USA ; 2 Ospedale Regionale di Lugano, Via Tesserete, 6900 Lugano, Ti Switzerland.
Quant Imaging Med Surg. 2014 Jun;4(3):173-80. doi: 10.3978/j.issn.2223-4292.2014.05.01.
To investigate chemical shift imaging (CSI) with in-phase and opposed-phase (OP) gradient-echo sequences as an alternative sequence to spin-echo T1 imaging for defining intra-medullary skeletal tumor extent.
This retrospective HIPAA-compliant study was approved by our institutional institutional review board (IRB). Twenty-three subjects with histologically-proven tumors (17 appendicular, 6 axial) underwent magnetic resonance imaging (MRI) with T1-weighted spin echo (T1SE), fluid-sensitive, CSI, and contrast-enhanced T1 sequences. One observer recorded intra-medullary tumor extent (millimeters), with 153 total measurements on each sequence. Red marrow grade [0 (none), 1 (<50%), 2 (50-75%) and 3 (>75%)] in each bone was recorded. Tumor extent on different sequences was compared (Student's t-test); the impact of red marrow grade on measurements was assessed (Spearman's correlation coefficient).
There was good agreement between measurements of tumor extent on T1SE and CSI sequences in all cases (T1SE-CSI measurement difference range 0-13.2 mm, P>0.05). Measurements from other sequences were significantly different from those of T1SE (P<0.05). As red marrow grade in the bone increased, a significant increase in measurement difference obtained on T1SE and CSI sequences was observed (P<0.001).
CSI is a potential alternative technique to T1SE imaging for defining the intra-medullary extent of a bone tumor, possibly especially useful in regions with abundant red marrow.
CSI could be an alternative technique to T1SE imaging for defining the intra-medullary extent of bone tumor by abundant red marrow in the surrounding bone.
研究同相位和反相位（OP）梯度回波序列的化学位移成像（CSI）作为自旋回波 T1 成像的替代序列，用于定义骨髓内骨骼肿瘤的范围。
这项回顾性 HIPAA 合规研究获得了我们机构的机构审查委员会（IRB）的批准。23 名经组织学证实的肿瘤患者（17 例四肢，6 例轴）接受了 T1 加权自旋回波（T1SE）、液体敏感 CSI 和对比增强 T1 序列的磁共振成像（MRI）检查。一名观察者记录了骨髓内肿瘤范围（毫米），每个序列有 153 个总测量值。记录了每个骨骼的红骨髓分级[0（无）、1（<50%）、2（50-75%）和 3（>75%）]。比较了不同序列上的肿瘤范围（Student's t 检验）；评估了红骨髓分级对测量值的影响（Spearman 相关系数）。
在所有病例中，T1SE 和 CSI 序列上的肿瘤范围测量值之间具有良好的一致性（T1SE-CSI 测量差值范围 0-13.2 毫米，P>0.05）。其他序列的测量值与 T1SE 的测量值显著不同（P<0.05）。随着骨骼中红骨髓分级的增加，在 T1SE 和 CSI 序列上获得的测量差值显著增加（P<0.001）。
CSI 是 T1SE 成像的潜在替代技术，可用于定义骨髓内骨肿瘤的范围，在周围骨骼富含红骨髓的情况下可能特别有用。
CSI 可能是一种替代 T1SE 成像的技术，可用于定义富含周围骨髓的骨肿瘤的骨髓内范围。
