Guerrero-Vargas Natalí N, Salgado-Delgado Roberto, Basualdo María Del Carmen, García Joselyn, Guzmán-Ruiz Mara, Carrero Julio C, Escobar Carolina, Buijs Ruud M
Departamento de Biología Celular y Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México DF 04510, Mexico.
Facultad de Ciencias, Universidad Autónoma de San Luis Potosí, Zona Universitaria c.p, 78290 San Luis Potosí, San Luis Potosí, Mexico.
J Neuroimmunol. 2014 Aug 15;273(1-2):22-30. doi: 10.1016/j.jneuroim.2014.05.012. Epub 2014 May 29.
Several studies have shown circadian variations in the response of the immune system suggesting a role of the suprachiasmatic nucleus (SCN). Here we show that lipopolysaccharide (LPS) administration in the beginning of the active period induced more severe responses in temperature and cytokines than LPS given in the rest period. Moreover night administered LPS increased SCN basal neuronal activity indicating a direct influence of inflammation on the SCN. Bilateral lesions of the SCN resulted in an increased inflammatory response to LPS demonstrating that an interaction between the SCN and the immune system modulates the intensity of the inflammatory response.
多项研究表明免疫系统的反应存在昼夜节律变化，提示视交叉上核（SCN）发挥了作用。在此我们发现，在活跃期开始时给予脂多糖（LPS）比在休息期给予LPS会引发更严重的体温和细胞因子反应。此外，夜间给予LPS会增加SCN的基础神经元活动，表明炎症对SCN有直接影响。SCN的双侧损伤导致对LPS的炎症反应增强，这表明SCN与免疫系统之间的相互作用调节了炎症反应的强度。
