Koszowski Bartosz, Rosenberry Zachary R, Viray Lauren C, Potts Jennifer L, Pickworth Wallace B
Battelle Memorial Institute, Human Exposure Assessment Laboratory (HEAL), Baltimore, Maryland.
Cancer Epidemiol Biomarkers Prev. 2014 Sep;23(9):1793-803. doi: 10.1158/1055-9965.EPI-14-0280. Epub 2014 Jun 12.
Despite considerable use of make your own (MYO) cigarettes worldwide and increasing use in the United States, relatively little is known about how these cigarettes are smoked and the resultant toxicant exposure.
In a laboratory study, we compared two types of MYO cigarettes-roll your own (RYO) and personal machine made (PMM)-with factory-made (FM) cigarettes in three groups of smokers who exclusively used RYO (n = 34), PMM (n = 23), or FM (n = 20). Within each group, cigarettes were smoked in three conditions: (i) after confirmed overnight tobacco abstinence; (ii) in an intense smoking paradigm; and (iii) without restrictions. All cigarettes were smoked ad lib through a smoking topography unit.
Plasma nicotine significantly increased after cigarettes in all conditions except PMM in the intense smoking paradigm. Puff volume, puff duration, total puff volume, and puff velocity did not differ between cigarette types but the puffs per cigarette and time to smoke were significantly smaller for RYO compared with PMM and FM. Regardless of the cigarette, participants consumed the first three puffs more vigorously than the last three puffs.
Despite the belief of many of their consumers, smoking MYO cigarettes is not a safe alternative to FM cigarettes. Like FM, MYO cigarettes expose their users to harmful constituents of tobacco smoke. Despite differences in size and design their puffing profiles are remarkably similar.
These data are relevant to health and regulatory considerations on the MYO cigarettes.
尽管自行制作（MYO）香烟在全球范围内被大量使用，且在美国的使用量也在不断增加，但对于这些香烟的吸食方式以及由此导致的有毒物质暴露情况，人们了解得相对较少。
在一项实验室研究中，我们将两种类型的MYO香烟——手卷烟（RYO）和个人机制卷烟（PMM）——与机制卷烟（FM）进行了比较，研究对象为三组吸烟者，他们分别只使用RYO（n = 34）、PMM（n = 23）或FM（n = 20）。在每组中，在三种条件下吸食香烟：（i）经过确认的夜间戒烟后；（ii）在高强度吸烟模式下；（iii）无限制。所有香烟均通过吸烟行为记录装置随意吸食。
除了在高强度吸烟模式下的PMM香烟外，在所有条件下吸食香烟后血浆尼古丁均显著增加。不同类型香烟之间的吸量、吸程、总吸量和吸速没有差异，但与PMM和FM相比，RYO每支香烟的吸数和吸烟时间显著更短。无论何种香烟，参与者吸食前三口的力度都比最后三口更大。
尽管许多消费者认为自行制作香烟是安全的，但它并非机制卷烟的安全替代品。与机制卷烟一样，自行制作香烟也会使使用者接触到烟草烟雾中的有害成分。尽管在尺寸和设计上存在差异，但它们的吸食特征非常相似。
这些数据与自行制作香烟的健康和监管考量相关。
