Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Metabolism. 2014 Aug;63(8):1056-62. doi: 10.1016/j.metabol.2014.05.002. Epub 2014 May 9.
In recent years links among vitamin D deficiency, inflammation and cardio-metabolic disease were proposed. As information regarding the associations between vitamin D and inflammatory markers in the general population is sparse, we investigated the associations of 25-hydroxy vitamin D [25(OH)D] with high-sensitivity C-reactive protein (hs-CRP), fibrinogen and white blood cell count (WBC).
MATERIALS/METHODS: The study population comprised 2723 men and women aged 25-88 years from the first follow-up of the Study of Health in Pomerania. Analyses of variance, linear and logistic regressions were performed to assess the associations between 25(OH)D and the three inflammatory markers. The models were adjusted for age, sex, waist circumference, diabetes mellitus, dyslipidemia, anti-inflammatory medication and month of blood sampling. The association between 25(OH)D and WBC was assessed separately in smokers (n = 718) and non-smokers (n = 2005) as effect modification was observed.
We detected a U-shaped association between 25(OH)D and hs-CRP with a nadir of 21-25 ng/ml in fully-adjusted linear regression models with restricted cubic splines (p < 0.01; p' < 0.01). We further detected an inverse association between 25(OH)D and fibrinogen (p < 0.01). In addition, there was an inverse association between 25(OH)D and WBC in smokers (p = 0.02) but no association in non-smokers (p = 0.73).
Our study confirms a potential role of 25(OH)D in chronic inflammation. Yet, different inflammatory biomarkers are differently associated with 25(OH)D. Beneficial effects of increasing 25(OH)D were observed for fibrinogen and WBC (in smokers only). In contrast, the U-shaped association between 25(OH)D and hs-CRP indicates that ever-increasing 25(OH)D concentrations may also be related to proinflammatory states.
近年来，人们提出了维生素 D 缺乏、炎症和心血管代谢疾病之间的联系。由于关于普通人群中维生素 D 与炎症标志物之间关系的信息较少，我们研究了 25-羟维生素 D [25(OH)D]与高敏 C 反应蛋白 (hs-CRP)、纤维蛋白原和白细胞计数 (WBC) 的关系。
材料/方法：该研究人群包括来自波罗的海健康研究第一随访的 2723 名年龄在 25-88 岁的男性和女性。采用方差分析、线性和逻辑回归分析评估 25(OH)D 与三种炎症标志物之间的关系。模型调整了年龄、性别、腰围、糖尿病、血脂异常、抗炎药物和采血月份。由于观察到了效应修饰，因此分别在吸烟者 (n = 718) 和非吸烟者 (n = 2005) 中评估了 25(OH)D 与 WBC 之间的关系。
在完全调整的线性回归模型中，我们通过限制三次样条检测到 25(OH)D 与 hs-CRP 之间呈 U 形关联，拐点为 21-25ng/ml (p < 0.01;p' < 0.01)。我们还检测到 25(OH)D 与纤维蛋白原之间呈负相关 (p < 0.01)。此外，在吸烟者中，25(OH)D 与 WBC 之间呈负相关 (p = 0.02)，但在非吸烟者中无相关性 (p = 0.73)。
本研究证实了 25(OH)D 在慢性炎症中的潜在作用。然而，不同的炎症生物标志物与 25(OH)D 的相关性不同。增加 25(OH)D 对纤维蛋白原和 WBC 有益 (仅在吸烟者中)。相反，25(OH)D 与 hs-CRP 之间的 U 形关联表明，不断增加的 25(OH)D 浓度也可能与促炎状态有关。
