Department of Gynecology and ObstetricsUniversity of Duisburg-Essen, D-45122 Essen, GermanyDivision of Genetic EpidemiologyDepartment of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Schöpfstrasse 41, A-6020 Innsbruck, AustriaVitateq Biotechnology GmbHA-6020 Innsbruck, Austria.
Department of Gynecology and ObstetricsUniversity of Duisburg-Essen, D-45122 Essen, GermanyDivision of Genetic EpidemiologyDepartment of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Schöpfstrasse 41, A-6020 Innsbruck, AustriaVitateq Biotechnology GmbHA-6020 Innsbruck, AustriaDepartment of Gynecology and ObstetricsUniversity of Duisburg-Essen, D-45122 Essen, GermanyDivision of Genetic EpidemiologyDepartment of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Schöpfstrasse 41, A-6020 Innsbruck, AustriaVitateq Biotechnology GmbHA-6020 Innsbruck, Austria
Endocr Connect. 2014 Sep;3(3):120-6. doi: 10.1530/EC-14-0053. Epub 2014 Jun 13.
Oxidative stress seems to be present in patients with polycystic ovary syndrome (PCOS). The aim of this study was to evaluate the correlation between characteristics of PCOS and serum concentrations of afamin, a novel binding protein for the antioxidant vitamin E. A total of 85 patients with PCOS and 76 control subjects were investigated in a pilot cross-sectional study design between 2009 and 2013 in the University Hospital of Essen, Germany. Patients with PCOS were diagnosed according to the Rotterdam ESHRE/ASRM-sponsored PCOS Consensus Workshop Group. Afamin and diagnostic parameters of PCOS were determined at early follicular phase. Afamin concentrations were significantly higher in patients with PCOS than in controls (odds ratio (OR) for a 10 mg/ml increase in afamin=1.3, 95% CI=1.08-1.58). This difference vanished in a model adjusting for age, BMI, free testosterone index (FTI), and sex hormone-binding globulin (SHBG) (OR=1.05, 95% CI=0.80-1.38). In patients with PCOS, afamin correlated significantly with homeostatic model assessment-insulin resistance (HOMA-IR), fasting glucose, BMI, FTI, and SHBG (P<0.001), but in a multivariate linear model, only HOMA-IR remained significantly associated with afamin (P=0.001). No correlation was observed between afamin and androgens, LH, FSH, LH/FSH ratio, antral follicle count, ovarian volume, or anti-Müllerian hormone. In conclusion, elevated afamin values may indicate a state of oxidative stress and inflammation, strongly associated with IR and offering an indicator of impaired glucose tolerance in patients with PCOS irrespective of obesity.
多囊卵巢综合征（PCOS）患者似乎存在氧化应激。本研究旨在评估 PCOS 特征与新型抗氧化维生素 E 结合蛋白 afamin 血清浓度之间的相关性。2009 年至 2013 年，在德国埃森大学医院，采用前瞻性横断面研究设计，共纳入 85 例 PCOS 患者和 76 例对照组。PCOS 患者根据 Rotterdam ESHRE/ASRM 赞助的 PCOS 共识工作组的标准进行诊断。在早卵泡期测定 afamin 和 PCOS 的诊断参数。与对照组相比，PCOS 患者的 afamin 浓度明显更高（afamin 增加 10mg/ml 的比值比（OR）=1.3，95%可信区间（CI）=1.08-1.58）。在调整年龄、BMI、游离睾酮指数（FTI）和性激素结合球蛋白（SHBG）的模型中，这一差异消失（OR=1.05，95%CI=0.80-1.38）。在 PCOS 患者中，afamin 与稳态模型评估胰岛素抵抗（HOMA-IR）、空腹血糖、BMI、FTI 和 SHBG 显著相关（P<0.001），但在多元线性模型中，只有 HOMA-IR 与 afamin 仍显著相关（P=0.001）。afamin 与雄激素、LH、FSH、LH/FSH 比值、窦卵泡计数、卵巢体积或抗苗勒管激素无相关性。总之，升高的 afamin 值可能表明存在氧化应激和炎症状态，与 IR 强烈相关，可作为 PCOS 患者葡萄糖耐量受损的指标，与肥胖无关。
