铜绿假单胞菌引起的上呼吸道-消化道污染及其在囊性纤维化中的意义。
Upper aero-digestive contamination by Pseudomonas aeruginosa and implications in Cystic Fibrosis.
机构信息
Laboratoire Universitaire de Biodiversité et d'Ecologie Microbienne (LUBEM-EA 3882), Université de Bretagne Occidentale, Université Européenne de Bretagne (UBO-UEB), 22 avenue C. Desmoulins, 29238 Brest Cedex, France.
Département de Chirurgie Orale, Pôle Organes des Sens, Centre Hospitalier Régional Universitaire (CHRU), 5 Av. Foch, 29609 Brest Cedex, France; Laboratoire Universitaire de Biodiversité et d'Ecologie Microbienne (LUBEM-EA 3882), (UBO-UEB), 22 avenue C. Desmoulins, 29238 Brest Cedex, France; CRCM, centre de Perharidy, Route de Perharidy, 29680 Roscoff, France.
出版信息
J Cyst Fibros. 2015 Jan;14(1):6-15. doi: 10.1016/j.jcf.2014.04.008. Epub 2014 Jun 3.
BACKGROUND
Cystic Fibrosis (CF) is a severe genetic disorder that is common among the Caucasian population. Bacterial respiratory infections are the main cause of morbidity and mortality in CF patients. Pseudomonas aeruginosa is the main pathogen of lower airways (LAW) decline.
METHOD
To understand chronic broncho-pulmonary colonization, a systematic review is conducted. The aim of our article is to identify the pathways of contamination in the upper aero-digestive tract.
RESULTS
A large number of articles report that P. aeruginosa is established first at nasopharyngeal sites. The vast majority of authors agree that the upper aero-digestive tract is the first location of colonization by P. aeruginosa and its presence appears to be predictive of subsequent broncho-pulmonary colonization.
CONCLUSION
This review supports the possible involvement of the nasal and paranasal sinuses and oral cavity as means of contamination.
背景
囊性纤维化（CF）是一种常见于白种人群体的严重遗传疾病。细菌呼吸道感染是 CF 患者发病和死亡的主要原因。铜绿假单胞菌是下呼吸道（LAW）下降的主要病原体。
方法
为了了解慢性支气管-肺定植，我们进行了系统评价。本文的目的是确定上呼吸道-消化道污染途径。
结果
大量文献报道铜绿假单胞菌首先定植于鼻咽部位。绝大多数作者都认为上呼吸道-消化道是铜绿假单胞菌定植的第一部位，其存在似乎可以预测随后的支气管-肺定植。
结论
这篇综述支持鼻腔和鼻窦以及口腔可能作为污染途径的可能性。
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