Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Environ Int. 2014 Sep;70:125-31. doi: 10.1016/j.envint.2014.05.011. Epub 2014 Jun 13.
Prenatal exposure to organophosphate pesticides (OPs) has been associated with adverse neurodevelopmental outcomes in childhood, including low IQ, pervasive developmental disorder (PDD), attention problems and ADHD. Many of these disorders involve impairments in social functioning. Thus, we investigated the relationship between biomarkers of prenatal OP exposure and impaired reciprocal social behavior in childhood, as measured by the Social Responsiveness Scale (SRS). Using a multi-ethnic urban prospective cohort of mother-infant pairs in New York City recruited between 1998 and 2002 (n=404) we examined the relation between third trimester maternal urinary levels of dialkylphosphate (ΣDAP) OP metabolites and SRS scores among 136 children who returned for the 7-9year visit. Overall, there was no association between OPs and SRS scores, although in multivariate adjusted models, associations were heterogeneous by race and by sex. Among blacks, each 10-fold increase in total diethylphosphates (ΣDEP) was associated with poorer social responsiveness (β=5.1 points, 95% confidence interval (CI) 0.8, 9.4). There was no association among whites or Hispanics, or for total ΣDAP or total dimethylphosphate (ΣDMP) biomarker levels. Additionally, stratum-specific models supported a stronger negative association among boys for ΣDEPs (β=3.5 points, 95% CI 0.2, 6.8), with no notable association among girls. Our results support an association of prenatal OP exposure with deficits in social functioning among blacks and among boys, although this may be in part reflective of differences in exposure patterns.
产前接触有机磷农药 (OPs) 与儿童期不良神经发育结局有关，包括智商低下、广泛性发育障碍 (PDD)、注意力问题和 ADHD。许多这些疾病涉及社交功能障碍。因此，我们研究了产前 OP 暴露的生物标志物与儿童时期受损的互惠社会行为之间的关系，通过社会反应量表 (SRS) 来衡量。我们使用了 1998 年至 2002 年在纽约市招募的母婴对的多民族城市前瞻性队列（n=404），研究了第三孕期母体尿中二烷基磷酸酯 (ΣDAP) OP 代谢物水平与 136 名返回进行 7-9 岁访问的儿童 SRS 评分之间的关系。总体而言，OPs 与 SRS 评分之间没有关联，尽管在多变量调整模型中，种族和性别存在异质性。在黑人中，总二乙基磷酸酯 (ΣDEP) 的每增加 10 倍与较差的社交反应能力相关（β=5.1 分，95%置信区间 (CI) 0.8, 9.4）。白人或西班牙裔或总 ΣDAP 或总二甲基磷酸酯 (ΣDMP) 生物标志物水平没有关联。此外，特定层的模型支持 ΣDEPs 中男孩之间更强的负相关（β=3.5 分，95%CI 0.2, 6.8），而女孩之间没有明显关联。我们的研究结果支持产前 OP 暴露与黑人以及男孩的社交功能障碍之间存在关联，尽管这可能部分反映了暴露模式的差异。
