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内皮抑素联合放疗治疗后荷瘤小鼠组织灌注的超声造影分析

Contrast-enhanced ultrasound analysis of tissue perfusion in tumor-bearing mice following treatment with endostatin combined with radiotherapy.

作者信息

Ge Wei, Zheng Yongfa, Tao Zezhang

机构信息

Department of Oncology, Renmin Hospital, Wuhan University, Wuhan, Hubei 430060, P.R. China.

Department of Otolaryngology, Renmin Hospital, Wuhan University, Wuhan, Hubei 430060, P.R. China.

出版信息

Exp Ther Med. 2014 May;7(5):1359-1363. doi: 10.3892/etm.2014.1594. Epub 2014 Feb 28.

DOI:10.3892/etm.2014.1594
PMID:24940439
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3991532/
Abstract

The aim of this study was to observe the effects of Endostar (recombinant human endostatin) and radiotherapy, singly or in combination, on blood flow in mouse tumour tissue using ultrasound imaging. The ultrasound contrast agent, SonoVue, was used for the contrast-enhanced ultrasound examinations. SonoLiver software was used to analyse dynamic vascular patterns (DVPs) in the contrast process. Blood perfusion data were collected and statistical analysis was performed for data processing. Results were presented as DVP curves and quantitative parameters. Quantitative parameters showed statistically significant (P<0.05) differences in peak strength, rise time, time to peak and mean transit time among the various treatment groups. Changes in tumour blood perfusion were quantified by the assessment of contrast-enhanced ultrasound parameters. The results indirectly reflected the degree of change in angiogenesis in the tumour following experimental intervention. Ultrasound contrast imaging effectively showed the extent of the changes in vascularity and flow state. Therefore, contrast-enhanced ultrasound is suitable for use as an indicator of blood flow changes in an experimental model.

摘要

本研究旨在利用超声成像观察重组人血管内皮抑制素（恩度）单独或联合放疗对小鼠肿瘤组织血流的影响。超声造影剂声诺维用于超声造影检查。使用SonoLiver软件分析造影过程中的动态血管模式（DVP）。收集血流灌注数据并进行统计分析以处理数据。结果以DVP曲线和定量参数表示。定量参数显示，各治疗组在峰值强度、上升时间、达峰时间和平均通过时间方面存在统计学显著差异（P<0.05）。通过评估超声造影参数对肿瘤血流灌注变化进行量化。结果间接反映了实验干预后肿瘤血管生成的变化程度。超声造影成像有效地显示了血管生成和血流状态的变化程度。因此，超声造影适用于作为实验模型中血流变化的指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cda7/3991532/5487e0738793/ETM-07-05-1359-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cda7/3991532/a4894cd6488a/ETM-07-05-1359-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cda7/3991532/6ecf6b2e79d6/ETM-07-05-1359-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cda7/3991532/0753976c7d49/ETM-07-05-1359-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cda7/3991532/5487e0738793/ETM-07-05-1359-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cda7/3991532/a4894cd6488a/ETM-07-05-1359-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cda7/3991532/6ecf6b2e79d6/ETM-07-05-1359-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cda7/3991532/0753976c7d49/ETM-07-05-1359-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cda7/3991532/5487e0738793/ETM-07-05-1359-g03.jpg

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Exp Ther Med. 2012 Jun;3(6):1018-1022. doi: 10.3892/etm.2012.534. Epub 2012 Mar 30.
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Early efficacy of Endostar combined with chemoradiotherapy for advanced cervical cancers.
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Radiat Oncol. 2020 Oct 17;15(1):240. doi: 10.1186/s13014-020-01684-3.
恩度联合放化疗治疗晚期宫颈癌的近期疗效
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PLoS One. 2012;7(4):e34646. doi: 10.1371/journal.pone.0034646. Epub 2012 Apr 9.
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