混合甘油三酯呼气试验：一种十二指肠中胰脂肪酶活性的非侵入性检测方法。

Mixed triglyceride breath test: a noninvasive test of pancreatic lipase activity in the duodenum.

作者信息

Vantrappen G R, Rutgeerts P J, Ghoos Y F, Hiele M I

机构信息

Department of Medicine, University Hospital Gasthuisberg, Leuven, Belgium.

出版信息

Gastroenterology. 1989 Apr;96(4):1126-34. doi: 10.1016/0016-5085(89)91632-6.

DOI:10.1016/0016-5085(89)91632-6

PMID:2494097

Abstract

A synthetic "mixed" triglyceride (1,3-distearoyl,2[13C]octanoyl glycerol), having a medium-chain fatty acid in the 2 position, was evaluated as a substrate for an exocrine pancreatic function test by comparing the 13CO2 breath excretion with the lipase output in the duodenum in 25 normal subjects, 29 patients with pancreatic disease, and 22 patients with steatorrhea of nonpancreatic origin. Excellent correlation was found in normal subjects and patients with pancreatic disease (r = 0.89) between lipase output in the duodenum and the 6-h cumulative 13CO2 excretion in breath, indicating that the mixed triglyceride breath test is an excellent noninvasive test of pancreatic lipase activity in the duodenum. As a test of exocrine pancreatic insufficiency, it has a sensitivity of 0.89 and a specificity of 0.81.

摘要

一种合成的“混合”甘油三酯（1,3-二硬脂酰基，2-[¹³C]辛酰基甘油），其2位含有中链脂肪酸，通过比较25名正常受试者、29名胰腺疾病患者和22名非胰腺源性脂肪泻患者十二指肠中脂肪酶的输出量与¹³CO₂呼出量，被评估为外分泌胰腺功能测试的底物。在正常受试者和胰腺疾病患者中，十二指肠中脂肪酶的输出量与6小时累积¹³CO₂呼出量之间发现了极好的相关性（r = 0.89），这表明混合甘油三酯呼气试验是一种极好的十二指肠中胰腺脂肪酶活性的非侵入性测试。作为外分泌胰腺功能不全的测试，其敏感性为0.89，特异性为0.81。