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表面修饰 RGD 肽的碳纳米管负载金纳米棒用于胃癌的靶向光声成像

RGD-conjugated silica-coated gold nanorods on the surface of carbon nanotubes for targeted photoacoustic imaging of gastric cancer.

机构信息

Xiangya Hospital of Central South University, 87 Xiangya Road, Changsha Hunan 410008, People's Republic of China.

Institute of Nano Biomedicine and Engineering, Key Laboratory for Thin Film and Microfabrication Technology of the Ministry of Education, Department of Instrument Science and Engineering, Research Institute of Translation Medicine, Shanghai JiaoTong University, Dongchuan Road 800, Shanghai 200240, People's Republic of China.

出版信息

Nanoscale Res Lett. 2014 May 27;9(1):264. doi: 10.1186/1556-276X-9-264. eCollection 2014.

DOI:10.1186/1556-276X-9-264
PMID:24948888
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4053550/
Abstract

Herein, we reported for the first time that RGD-conjugated silica-coated gold nanorods on the surface of multiwalled carbon nanotubes were successfully used for targeted photoacoustic imaging of in vivo gastric cancer cells. A simple strategy was used to attach covalently silica-coated gold nanorods (sGNRs) onto the surface of multiwalled carbon nanotubes (MWNTs) to fabricate a hybrid nanostructure. The cross-linked reaction occurred through the combination of carboxyl groups on the MWNTs and the amino group on the surface of sGNRs modified with a silane coupling agent. RGD peptides were conjugated with the sGNR/MWNT nanostructure; resultant RGD-conjugated sGNR/MWNT probes were investigated for their influences on viability of MGC803 and GES-1 cells. The nude mice models loaded with gastric cancer cells were prepared, the RGD-conjugated sGNR/MWNT probes were injected into gastric cancer-bearing nude mice models via the tail vein, and the nude mice were observed by an optoacoustic imaging system. Results showed that RGD-conjugated sGNR/MWNT probes showed good water solubility and low cellular toxicity, could target in vivo gastric cancer cells, and obtained strong photoacoustic imaging in the nude model. RGD-conjugated sGNR/MWNT probes will own great potential in applications such as targeted photoacoustic imaging and photothermal therapy in the near future.

摘要

在这里，我们首次报道了表面接枝 RGD 的硅壳金纳米棒修饰的多壁碳纳米管成功用于体内胃癌细胞的靶向光声成像。采用一种简单的策略，通过碳纳米管表面的羧基与硅烷偶联剂修饰的金纳米棒表面的氨基之间的交联反应，将硅壳金纳米棒（sGNRs）共价接枝到多壁碳纳米管（MWNTs）表面，制备了一种杂化纳米结构。RGD 肽与 sGNR/MWNT 纳米结构偶联；研究了所得 RGD 修饰的 sGNR/MWNT 探针对 MGC803 和 GES-1 细胞活力的影响。通过尾静脉向荷胃癌裸鼠模型注射 RGD 修饰的 sGNR/MWNT 探针，用光声成像系统观察裸鼠。结果表明，RGD 修饰的 sGNR/MWNT 探针具有良好的水溶性和低细胞毒性，能够靶向体内胃癌细胞，并在裸鼠模型中获得强的光声成像。RGD 修饰的 sGNR/MWNT 探针在靶向光声成像和光热治疗等方面具有广阔的应用前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f4c/4053550/65629de435d9/1556-276X-9-264-10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f4c/4053550/2d4444765407/1556-276X-9-264-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f4c/4053550/3e46d58155f4/1556-276X-9-264-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f4c/4053550/049c1e4dbd52/1556-276X-9-264-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f4c/4053550/81da68ca6b15/1556-276X-9-264-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f4c/4053550/75a156865126/1556-276X-9-264-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f4c/4053550/ec4c742e295d/1556-276X-9-264-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f4c/4053550/04e402af5d43/1556-276X-9-264-8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f4c/4053550/dfd44ba2168f/1556-276X-9-264-9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f4c/4053550/65629de435d9/1556-276X-9-264-10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f4c/4053550/2d4444765407/1556-276X-9-264-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f4c/4053550/3e46d58155f4/1556-276X-9-264-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f4c/4053550/049c1e4dbd52/1556-276X-9-264-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f4c/4053550/81da68ca6b15/1556-276X-9-264-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f4c/4053550/75a156865126/1556-276X-9-264-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f4c/4053550/ec4c742e295d/1556-276X-9-264-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f4c/4053550/04e402af5d43/1556-276X-9-264-8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f4c/4053550/dfd44ba2168f/1556-276X-9-264-9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f4c/4053550/65629de435d9/1556-276X-9-264-10.jpg

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