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耳真菌病;临床特征、易患因素和治疗意义。

Otomycosis; clinical features, predisposing factors and treatment implications.

机构信息

Lt Col Khurshid Anwar, MBBS, FCPS (ENT), Combined Military Hospital, Attock Cantt, Punjab, Pakistan.

Wg Cdr (Lt Col) Muhammad Shahid Gohar, MBBS, FCPS (ENT), Pakistan Aeronautical Complex Hospital, Kamra (Disstt: Attock), Punjab, Pakistan.

出版信息

Pak J Med Sci. 2014 May;30(3):564-7. doi: 10.12669/pjms.303.4106.

Abstract

UNLABELLED

Objectives : The aim of this study was to determine the frequency of otomycosis, the clinical presentation, predisposing factors and treatment outcomes.

METHODS

This observational study was conducted at ENT department of Combined Military Hospital Attock, from October, 2010 to September, 2012. Convenient sample comprising 180 patients of both sexes and all age groups were selected from ENT OPD. The frequency, predisposing factors and most common symptoms of otomycosis were recorded. The response to different antifungal agents was also observed. RESULTS were recorded in percentages.

RESULTS

There were 180 patients with documented diagnosis of otomycosis. There were 107 (59%) males and 73 (41%) females. The age of patients ranged from 1½ years to 75 years with a mean age of 38.5 years. Mean follow up time was 2 years. Most common presenting symptom was hearing loss (77.7%) followed by pruritis (68.8%) and otalgia (40%). We prescribed 1% clotrimazole drops or lotion in 58% patients and 2% salicylic acid in 31% cases. Both of these agents are effective. Topical 1% clotrimazole drops yielded highest resolution rate with lowest recurrent rate. Overall 149 (83%) patients were improved with initial treatment and 31 (17%) did not respond to initial treatment. Eight (4.4%) patients had a history of otological procedures. Four (2.2%) patients had canal wall down procedures that resulted in mastoid cavity. To analyse the efficacy of 1% clotrimazole and 2% salicylic acid we applied Z-Test to calculate the difference between 2 proportions of patients before treatment with those patients who remained uncured after treatment.

CONCLUSION

Otomycosisis commonly presented with decreased hearing, pruritis, otalgia & otorrhoea. It usually resolves with local toilet of ear and instillation of antifungal agents. Eradication of disease is difficult in presence of a mastoid cavity and metabolic diseases like diabetes mellitus.

摘要

目的

本研究旨在确定耳真菌病的频率、临床表现、诱发因素和治疗结果。

方法

本观察性研究于 2010 年 10 月至 2012 年 9 月在阿托克联合军事医院耳鼻喉科进行。从耳鼻喉科门诊方便选取了 180 名男女患者和所有年龄组的患者。记录了耳真菌病的频率、诱发因素和最常见的症状。还观察了不同抗真菌药物的反应。结果以百分比记录。

结果

有 180 名患者被确诊为耳真菌病。其中 107 名(59%)为男性,73 名(41%)为女性。患者年龄从 1 岁半到 75 岁,平均年龄为 38.5 岁。平均随访时间为 2 年。最常见的首发症状是听力下降(77.7%),其次是瘙痒(68.8%)和耳痛(40%)。我们为 58%的患者开了 1%克霉唑滴耳液或洗剂,为 31%的患者开了 2%水杨酸。这两种药物都有效。局部使用 1%克霉唑滴耳液的缓解率最高,复发率最低。总的来说,149 名(83%)患者经初始治疗后得到改善,31 名(17%)患者对初始治疗无反应。8 名(4.4%)患者有耳部手术史。4 名(2.2%)患者进行了鼓室成形术,导致乳突腔。为了分析 1%克霉唑和 2%水杨酸的疗效,我们应用 Z 检验计算治疗前患者与治疗后未治愈患者的两组患者之间的差异。

结论

耳真菌病常表现为听力下降、瘙痒、耳痛和耳漏。通常通过局部耳部清洁和滴注抗真菌药物来解决。在乳突腔和代谢性疾病(如糖尿病)存在的情况下,疾病的根除较为困难。

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