Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Mycopathologia. 2014 Aug;178(1-2):79-83. doi: 10.1007/s11046-014-9759-z. Epub 2014 Jun 21.
Ochroconis humicola, a fish pathogen, is rarely reported to cause disease in human. We report its first isolation from nasal tissue of a human immunodeficiency virus-positive young female patient. Histopathologically, the nasal mass was diagnosed as esthesioneuroblastoma. She presented with right-sided nasal obstruction and bleeding for two and half months. Computed tomography scan showed the nasal mass filling the whole right nasal cavity, maxillary, ethmoid and sphenoid sinuses. The direct microscopy of the nasal tissue and mucin demonstrated the presence of septate hyphae. On culture, O. humicola was isolated from the same tissue and the fungus was identified by morphologic, physiologic and molecular data including sequencing of ITS and 28S rDNA regions. No antifungal was prescribed, and the whole mass was resected out by endoscopic surgery. The patient was treated further by radical radiotherapy. After 1 year of follow-up, patient is stable with no recurrence of tumour. The role of this fungus was not clear, as it may be bystander or producing allergic fungal rhinosinusitis.
棘壳炱菌，一种鱼类病原体，很少有报道称其会导致人类患病。我们首次报告了从一名人类免疫缺陷病毒阳性的年轻女性患者的鼻腔组织中分离出该菌。组织病理学上，该鼻腔肿块被诊断为嗅神经母细胞瘤。患者因右侧鼻塞和出血持续了两个半月就诊。计算机断层扫描显示，鼻腔肿块充满了整个右侧鼻腔、上颌窦、筛窦和蝶窦。鼻腔组织和黏蛋白的直接显微镜检查显示存在分隔菌丝。从同一组织中分离出棘壳炱菌进行培养，并通过形态学、生理学和分子数据（包括 ITS 和 28S rDNA 区域的测序）鉴定了该真菌。未开具任何抗真菌药物，通过内镜手术切除了整个肿块。患者进一步接受根治性放疗。随访 1 年后，患者病情稳定，无肿瘤复发。该真菌的作用尚不清楚，可能是旁观者或产生变应性真菌性鼻鼻窦炎。
